Studies on the Thrombin-Like Principles of Agkistrodon acutus Venom.Ⅱ.Studies on Activity of Enzymology and Hemotology

XIAO Chang-hua; HE Li-feng; TANG Shao-zong; YANG Jun-ru

Volume 10 Issue 3

May 1989

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Article Navigation > Zoological Research > 1989 > 10(3): 213-218

XIAO Chang-hua, HE Li-feng, TANG Shao-zong, YANG Jun-ru. Studies on the Thrombin-Like Principles of Agkistrodon acutus Venom.Ⅱ.Studies on Activity of Enzymology and Hemotology. Zoological Research, 1989, 10(3): 213-218.

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Studies on the Thrombin-Like Principles of Agkistrodon acutus Venom.Ⅱ.Studies on Activity of Enzymology and Hemotology

Kunming Institute of Zoology,Acadmia sinica

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 1989-08-22

Abstract

Abstract

Four kinds of thrombin-like principles (TLP) for comparing their enzymological properties were studied.In vitro,the result shows that TLP[4]>TLP[3]>TLP[1]>TLP[2] for the activity of coagulation and the activity of arginineesterase is higher in TLP[1] and TLP[2] than that in TLP[3] and TLP[4].Defibrination of TLP[1] or TLP[2] is strong,but hemocoagulation of TLP[4] and TLP[3] is strong in vivo.The four enzymes show differences in influence of Ca,pH,EDTA,temperature and heparin upon the activities of the enzymes.The result is similar to the thrombin-like enzymes obtained from Bothrops asper venom.The rerult may make sense in their application.
- Agkistrodon acutus,
- defibrinase,
- hemocoagulase