Volume 29 Issue 1
Jan.  2008
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SHI Jun-wei, ZOU Hong, JIN Mei-lei. Assessing Exploratory Behavior and Memory in ICR, BALB/c and C57BL/6 Mice Using Habituation. Zoological Research, 2008, 29(1): 49-55.
Citation: SHI Jun-wei, ZOU Hong, JIN Mei-lei. Assessing Exploratory Behavior and Memory in ICR, BALB/c and C57BL/6 Mice Using Habituation. Zoological Research, 2008, 29(1): 49-55.

Assessing Exploratory Behavior and Memory in ICR, BALB/c and C57BL/6 Mice Using Habituation

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  • Author Bio:

    SHI Jun-wei

  • Corresponding author: JIN Mei-lei
  • Received Date: 2007-11-05
  • Rev Recd Date: 2007-12-17
  • Publish Date: 2008-02-22
  • Differences in exploratory, rearing and locomotion activity of ICR, BALB/c and C57BL/6 strain were investigated by a 16-hole board task and an open field with an automated infrared detecting system. ICR mice had the highest response rate while C57BL/6 mice had the lowest. It took less time for ICR mice to get used to a new environment and its performance in memory testing was also superior to C57BL/6 mice. The results confirmed the feasibility of using a hole-board test to assess memory. Comparisons between the trend of rearing and hole-poking activity demonstrated that the rearing behavior of mice, to a certain degree, reflected its exploratory and cognitive ability. Our results provided firm support for the notion that selection of a mouse strain is essential when conducting studies on higher cognitive behavior in mice.
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