Volume 27 Issue 5
Sep.  2006
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WANG Jian-hua , , OUYANG Dong-yun, WANG Yuan-yuan, ZHENG Yong-tang , *. Progress in Anti-HIV-1 Actions of Ribosome Inactivating Proteins. Zoological Research, 2006, 27(5): 541-548.
Citation: WANG Jian-hua , , OUYANG Dong-yun, WANG Yuan-yuan, ZHENG Yong-tang , *. Progress in Anti-HIV-1 Actions of Ribosome Inactivating Proteins. Zoological Research, 2006, 27(5): 541-548.

Progress in Anti-HIV-1 Actions of Ribosome Inactivating Proteins

  • Received Date: 2006-06-09
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2006-10-22
  • The anti-HIV-1 research history of ribosome inactivating proteins (RIPs) can be traced back to McGrath's work in 1989. They are important representatives, which guide further research, of natural anti-HIV products or leading compounds. The enzymatic activities and anti-HIV-1 actions of RIPs were introduced initially in this paper, followed by a detailed discussion about the potential anti-HIV-1 mechanisms. The discussion mainly focuses on the relationships with anti-HIV-1 enzymatic activities, induction of apoptosis of HIV-1 infected cells and responding cell signaling, the production of reactive oxygen species, the HIV-1 integrase inhibition effect. The anti-HIV-1 structure-functional relationship of RIPs and the structural modifications were also covered. Systemic and intensive studies of RIPs' antiviral actions will increase their possibility as clinical anti-HIV/AIDS agents.
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