Volume 26 Issue 3
May  2005
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WANG Li-ju, GAO Guo-fu, BAI Shi-ping, LIU Zhi-gang, LIANG Jian-guo et al.. A Thrombin Inhibitor from Ixodid Tick,Ixodide sinesis. Zoological Research, 2005, 26(3): 328-331.
Citation: WANG Li-ju, GAO Guo-fu, BAI Shi-ping, LIU Zhi-gang, LIANG Jian-guo et al.. A Thrombin Inhibitor from Ixodid Tick,Ixodide sinesis. Zoological Research, 2005, 26(3): 328-331.

A Thrombin Inhibitor from Ixodid Tick,Ixodide sinesis

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2005-06-22
  • A novel thrombin inhibitor was identified and purified from salivary glands of ixodid tick,Ixodide sinesis by gel filtration and RP-HPLC. The molecular weight was 6.356 kDa determined by MALDI-TOF mass spectra. It was different from any known serine protease inhibitors identified from ixodid ticks. This inhibitor inhibited thrombin with strong potency,and exhibited no obvious effects on factor Xa and trypsin. The thrombin inhibitor may be used as a candidate to develop vaccine to control ticks.
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