Volume 14 Issue 4
Jul.  1993
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CHEN Yan-qin, XU Shi-tong, OU Ying-qi. The Modulation of Medial Septal Nucleus on Learning-Dependent Long-Term Potentiation in The Rat Dentate Gyrus. Zoological Research, 1993, 14(4): 335-340.
Citation: CHEN Yan-qin, XU Shi-tong, OU Ying-qi. The Modulation of Medial Septal Nucleus on Learning-Dependent Long-Term Potentiation in The Rat Dentate Gyrus. Zoological Research, 1993, 14(4): 335-340.

The Modulation of Medial Septal Nucleus on Learning-Dependent Long-Term Potentiation in The Rat Dentate Gyrus

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 1993-11-22
  • Population Spike (PS) elicited by perforant path stimulation in the dentate gyrus (DG) of freely moving rats was recorded.Rats were trained on discrimination learning.The results were as follows:(1)High-frequency stimulation (HFS) of the medial septal nucleus (MS) temporarily caused a suppression of PS in DG;(2) HFS of MS following daily training session caused a significant suppression of the development of learning-dependent long-term potentiation (LDLTP),and correspondingly,a prevention of the acquisition of discriminative responding;(3)HFS of MS resulted in a significant decrease (P<0.01) of the maximal level of the potentiation of PS amplitude.These results suggest that MS exerts an inhibitory modulated effects on LDLTP in DG,which mainly affects the development of LDLTP.
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