Volume 30 Issue 2
Mar.  2009
Turn off MathJax
Article Contents
LIU Xiao-fen, YAN Zi-li, WANG Jian-hong, HU Xin-tian, MA Yuan-ye. Effects of Withdrawal on Y-maze Spatial Recognition Memory in Mice after Long-term Morphine Injection. Zoological Research, 2009, 30(2): 199-203. doi: 10.3724/SP.J.1141.2009.02199
Citation: LIU Xiao-fen, YAN Zi-li, WANG Jian-hong, HU Xin-tian, MA Yuan-ye. Effects of Withdrawal on Y-maze Spatial Recognition Memory in Mice after Long-term Morphine Injection. Zoological Research, 2009, 30(2): 199-203. doi: 10.3724/SP.J.1141.2009.02199

Effects of Withdrawal on Y-maze Spatial Recognition Memory in Mice after Long-term Morphine Injection

doi: 10.3724/SP.J.1141.2009.02199
More Information
  • Corresponding author: HU Xin-tian, MA Yuan-ye
  • Received Date: 2008-10-07
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2009-04-22
  • Acute drug use modifies brain function in critical ways, and prolonged drug use causes pervasive changes in brain function that persist long after withdrawal. Our previous studies proved that acute or four-day morphine injection impaired mice spatial recognition memory in the Y-maze, but the impairment was short and reversible. In the present study, morphine or saline (40 mg/ kg·day, ip) was injected into mice for 21 days. Spatial recognition memory was tested in the Y-maze on the 2nd, 9th and 19th withdrawal day. Our results showed that spatial recognition memory of morphine-injected mice was impaired on each of the three test days. Our study clearly suggests that long-term morphine use leads to more persistent impairments of spatial recognition memory.
  • loading
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2664) PDF downloads(1962) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return