Effects of Withdrawal on Y-maze Spatial Recognition Memory in Mice after Long-term Morphine Injection

LIU Xiao-fen; YAN Zi-li; WANG Jian-hong; HU Xin-tian; MA Yuan-ye

doi:10.3724/SP.J.1141.2009.02199

Volume 30 Issue 2

Mar. 2009

Turn off MathJax

Article Contents

Article Navigation > Zoological Research > 2009 > 30(2): 199-203

LIU Xiao-fen, YAN Zi-li, WANG Jian-hong, HU Xin-tian, MA Yuan-ye. Effects of Withdrawal on Y-maze Spatial Recognition Memory in Mice after Long-term Morphine Injection. Zoological Research, 2009, 30(2): 199-203. doi: 10.3724/SP.J.1141.2009.02199

Citation:

LIU Xiao-fen, YAN Zi-li, WANG Jian-hong, HU Xin-tian, MA Yuan-ye. Effects of Withdrawal on Y-maze Spatial Recognition Memory in Mice after Long-term Morphine Injection. Zoological Research, 2009, 30(2): 199-203. doi: 10.3724/SP.J.1141.2009.02199

Citation:

PDF( 266 KB)

Effects of Withdrawal on Y-maze Spatial Recognition Memory in Mice after Long-term Morphine Injection

doi: 10.3724/SP.J.1141.2009.02199

1.
Laboratory of Primate Neuroscience Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China; 2. Laboratory of Sensorymotor Integration Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China;
3.
Kunming Primate Research Center, the Chinese Academy of Sciences, Kunming 650223, China;
4.
Graduate School of the Chinese Academy of Sciences, Beijing 100049

More Information

Corresponding author: HU Xin-tian, MA Yuan-ye
Received Date: 2008-10-07
Rev Recd Date: 1900-01-01
Publish Date: 2009-04-22

Abstract

Abstract

Acute drug use modifies brain function in critical ways, and prolonged drug use causes pervasive changes in brain function that persist long after withdrawal. Our previous studies proved that acute or four-day morphine injection impaired mice spatial recognition memory in the Y-maze, but the impairment was short and reversible. In the present study, morphine or saline (40 mg/ kg·day, ip) was injected into mice for 21 days. Spatial recognition memory was tested in the Y-maze on the 2nd, 9th and 19th withdrawal day. Our results showed that spatial recognition memory of morphine-injected mice was impaired on each of the three test days. Our study clearly suggests that long-term morphine use leads to more persistent impairments of spatial recognition memory.
- Y-maze,
- Spatial recognition memory,
- Morphine,
- Withdrawal,
- Withdrawal symptoms