Volume 29 Issue 3
May  2008
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NIU Yi-dong, LIANG Shu-long. Mammalian Models Based on RCAS-TVA Technique. Zoological Research, 2008, 29(3): 335-345. doi: 10.3724/SP.J.1141.2008.03335
Citation: NIU Yi-dong, LIANG Shu-long. Mammalian Models Based on RCAS-TVA Technique. Zoological Research, 2008, 29(3): 335-345. doi: 10.3724/SP.J.1141.2008.03335

Mammalian Models Based on RCAS-TVA Technique

doi: 10.3724/SP.J.1141.2008.03335
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  • Corresponding author: NIU Yi-dong
  • Received Date: 2008-01-17
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2008-06-22
  • The retroviral vector (RCAS) has been widely used in avian system to study development and diseases, but is not suitable for mammals which do not produce the retrovirus receptor TVA. In this review, we trace the current uses of RCAS-TVA approach in mammalian system with improved strategies, including generation of tv-a transgenic mice, use of soluble TVA receptor and retroviral receptor-ligand fusion proteins, improvement of RCAS vectors, and compare a series of mammalian models in variant studies of gene function, development, oncogenesis and gene therapy. All those studies demonstrate that the RCAS-TVA based mammalian models are powerful tools for understanding the mechanisms and target treating of human diseases.
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