Evolution of p53 pathway-related genes provides insights into anticancer mechanisms of natural longevity in cetaceans

Xing Liu; Fei Yang; Yi Li; Zhen-Peng Yu; Xin Huang; Lin-Xia Sun; Wen-Hua Ren; Guang Yang; Shi-Xia Xu

doi:10.24272/j.issn.2095-8137.2023.058

Volume 44 Issue 5

Sep. 2023

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Article Navigation > Zoological Research > 2023 > 44(5): 947-949

Xing Liu, Fei Yang, Yi Li, Zhen-Peng Yu, Xin Huang, Lin-Xia Sun, Wen-Hua Ren, Guang Yang, Shi-Xia Xu. Evolution of p53 pathway-related genes provides insights into anticancer mechanisms of natural longevity in cetaceans. Zoological Research, 2023, 44(5): 947-949. doi: 10.24272/j.issn.2095-8137.2023.058

Citation:

Xing Liu, Fei Yang, Yi Li, Zhen-Peng Yu, Xin Huang, Lin-Xia Sun, Wen-Hua Ren, Guang Yang, Shi-Xia Xu. Evolution of p53 pathway-related genes provides insights into anticancer mechanisms of natural longevity in cetaceans. Zoological Research, 2023, 44(5): 947-949. doi: 10.24272/j.issn.2095-8137.2023.058

Citation:

Xing Liu, Fei Yang, Yi Li, Zhen-Peng Yu, Xin Huang, Lin-Xia Sun, Wen-Hua Ren, Guang Yang, Shi-Xia Xu. Evolution of p53 pathway-related genes provides insights into anticancer mechanisms of natural longevity in cetaceans. Zoological Research, 2023, 44(5): 947-949. doi: 10.24272/j.issn.2095-8137.2023.058

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Evolution of p53 pathway-related genes provides insights into anticancer mechanisms of natural longevity in cetaceans

doi: 10.24272/j.issn.2095-8137.2023.058

1.
Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210023, China

Supplementary data to this article can be found online.
The authors declare that they have no competing interests.
S.X.X. designed the study. X.L. was responsible for the data collection and analysis. S.X.X. and X.L. drafted the manuscript. S.X.X. revised the manuscript. F.Y., Y.L., X.H., and L.X.S. participated in the data collection. Z.P.Y., W.H.R., and G.Y. helped edit the manuscript. All authors read and approved the final version of the manuscript.

Funds: This work was supported by the National Key Program of Research and Development, Ministry of Science and Technology of China (2022YFF1301600), National Natural Science Foundation of China (32070409, 32270453 to S.X.X.), Priority Academic Program Development of Jiangsu Higher Education Institutions to G.Y. and S.X.X., and Qing Lan Project of Jiangsu Province to S.X.X.

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Corresponding author: E-mail: xushixia@njnu.edu.cn
Received Date: 2023-04-09
Accepted Date: 2023-09-11

Published Online: 2023-09-11

Publish Date: 2023-09-18

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References(10)

References

[1]	Abegglen LM, Caulin AF, Chan A, et al. 2015. Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans. JAMA, 314(17): 1850−1860. doi: 10.1001/jama.2015.13134
[2]	Al-Ostoot FH, Salah S, Khamees HA, et al. 2021. Tumor angiogenesis: Current challenges and therapeutic opportunities. Cancer Treatment and Research Communications, 28: 100422. doi: 10.1016/j.ctarc.2021.100422
[3]	Brugarolas JB, Vazquez F, Reddy A, et al. 2003. TSC2 regulates VEGF through mTOR-dependent and-independent pathways. Cancer Cell, 4(2): 147−158. doi: 10.1016/S1535-6108(03)00187-9
[4]	Cha HJ, Yim H. 2013. The accumulation of DNA repair defects is the molecular origin of carcinogenesis. Tumor Biology, 34(6): 3293−3302. doi: 10.1007/s13277-013-1038-y
[5]	Gorbunova V, Seluanov A, Zhang ZD, et al. 2014. Comparative genetics of longevity and cancer: insights from long-lived rodents. Nature Reviews Genetics, 15(8): 531−540. doi: 10.1038/nrg3728
[6]	Nagy JD, Victor EM, Cropper JH. 2007. Why don't all whales have cancer? A novel hypothesis resolving Peto's paradox. Integrative and Comparative Biology, 47(2): 317−328. doi: 10.1093/icb/icm062
[7]	Peto R, Roe FJ, Lee PN, et al. 1975. Cancer and ageing in mice and men. British Journal of Cancer, 32(4): 411−426. doi: 10.1038/bjc.1975.242
[8]	Tacutu R, Thornton D, Johnson E, et al. 2018. Human ageing genomic resources: new and updated databases. Nucleic Acids Research, 46(D1): D1083−D1090. doi: 10.1093/nar/gkx1042
[9]	Vellai T, Takacs-Vellai K, Zhang Y, et al. 2003. Influence of TOR kinase on lifespan in C. elegans. Nature, 426(6967): 620.
[10]	Wu JB, Strawn TL, Luo M, et al. 2015. Plasminogen activator inhibitor-1 inhibits angiogenic signaling by uncoupling vascular endothelial growth factor receptor-2-α_Vβ₃ integrin cross talk. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(1): 111−120. doi: 10.1161/ATVBAHA.114.304554