Volume 44 Issue 3
May  2023
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Dan Yang, Xiao-Jing Li, De-Zhen Tu, Xiu-Li Li, Bin Wei. Advances in viral encephalitis: Viral transmission, host immunity, and experimental animal models. Zoological Research, 2023, 44(3): 525-542. doi: 10.24272/j.issn.2095-8137.2023.025
Citation: Dan Yang, Xiao-Jing Li, De-Zhen Tu, Xiu-Li Li, Bin Wei. Advances in viral encephalitis: Viral transmission, host immunity, and experimental animal models. Zoological Research, 2023, 44(3): 525-542. doi: 10.24272/j.issn.2095-8137.2023.025

Advances in viral encephalitis: Viral transmission, host immunity, and experimental animal models

doi: 10.24272/j.issn.2095-8137.2023.025
The authors declare that they have no competing interests.
D.Y., X.J.L., and D.Z.T. wrote the original draft and constructed the figures and tables. X.L.L. and B.W. conceptualized, wrote, and edited the manuscript. All authors read and approved the final version of the manuscript.
#Authors contributed equally to this work
Funds:  This work was supported by the National Natural Science Foundation of China (81825011, 81930038, 81961160738), Program of Shanghai Academic/Technology Research Leader (22XD1400800), and Strategic Priority Research Program of the Chinese Academy of Sciences (XDB19030200)
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  • Viral infections have led to many public health crises and pandemics in the last few centuries. Neurotropic virus infection-induced viral encephalitis (VE), especially the symptomatic inflammation of the meninges and brain parenchyma, has attracted growing attention due to its high mortality and disability rates. Understanding the infectious routes of neurotropic viruses and the mechanism underlying the host immune response is critical to reduce viral spread and improve antiviral therapy outcomes. In this review, we summarize the common categories of neurotropic viruses, viral transmission routes in the body, host immune responses, and experimental animal models used for VE study to gain a deeper understanding of recent progress in the pathogenic and immunological mechanisms under neurotropic viral infection. This review should provide valuable resources and perspectives on how to cope with pandemic infections.
  • The authors declare that they have no competing interests.
    D.Y., X.J.L., and D.Z.T. wrote the original draft and constructed the figures and tables. X.L.L. and B.W. conceptualized, wrote, and edited the manuscript. All authors read and approved the final version of the manuscript.
    #Authors contributed equally to this work
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