Large animal models of cardiac ischemia-reperfusion injury: Where are we now?

doi: 10.24272/j.issn.2095-8137.2022.487

• Attaur Rahman^{1, 2, 3} , 
• Yuhao Li^{1, 2} , 
• To-Kiu Chan^{1, 2} , 
• Hui Zhao^{4, 5, 6, 7} , 
• Yaozu Xiang⁸ , 
• Xing Chang⁹ , 
• Hao Zhou^{10, 11} , 
• Dachun Xu^{12 ,  ,}  , 
• Sang-Bing Ong^{1, 2, 7, 13, 14, 15 ,  ,} 

• 1.

  Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China

• 2.

  Centre for Cardiovascular Genomics and Medicine (CCGM), Lui Che Woo Institute Innovative Medicine, The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China

• 3.

  College of Veterinary Sciences and Animal Husbandry, Abdul Wali Khan University Mardan, Mardan, Khyber Pakhtunkhwa 23200, Pakistan

• 4.

  School of Biomedical Sciences, CUHK-GIBH CAS Joint Laboratory on Stem Cell and Regenerative Medicine, The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China

• 5.

  Institute for Tissue Engineering and Regenerative Medicine (iTERM), The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China

• 6.

  SBS Core Laboratory, CUHK Shenzhen Research Institute, Shenzhen, Guangdong 518172, China

• 7.

  Kunming Institute of Zoology – The Chinese University of Hong Kong (KIZ-CUHK) Joint Laboratory of Bioresources and Molecular Research of Common Diseases, Hong Kong SAR, China

• 8.

  Shanghai East Hospital, Key Laboratory of Arrhythmias of the Ministry of Education of China, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China

• 9.

  Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

• 10.

  Department of Cardiology, Chinese People’s Liberation Army General Hospital, Beijing 100853, China

• 11.

  Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA

• 12.

  Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China

• 13.

  Hong Kong Hub of Paediatric Excellence (HK HOPE), Hong Kong Children’s Hospital (HKCH), Kowloon Bay, Hong Kong SAR, China

• 14.

  CUHK Shenzhen Research Institute (SZRI), Shenzhen, Guangdong 518172, China

• 15.

  Neural, Vascular, and Metabolic Biology Thematic Research Program, School of Biomedical Sciences, The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China