Volume 44 Issue 3
May  2023
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Article Contents
Attaur Rahman, Yuhao Li, To-Kiu Chan, Hui Zhao, Yaozu Xiang, Xing Chang, Hao Zhou, Dachun Xu, Sang-Bing Ong. Large animal models of cardiac ischemia-reperfusion injury: Where are we now?. Zoological Research, 2023, 44(3): 591-603. doi: 10.24272/j.issn.2095-8137.2022.487
Citation: Attaur Rahman, Yuhao Li, To-Kiu Chan, Hui Zhao, Yaozu Xiang, Xing Chang, Hao Zhou, Dachun Xu, Sang-Bing Ong. Large animal models of cardiac ischemia-reperfusion injury: Where are we now?. Zoological Research, 2023, 44(3): 591-603. doi: 10.24272/j.issn.2095-8137.2022.487

Large animal models of cardiac ischemia-reperfusion injury: Where are we now?

doi: 10.24272/j.issn.2095-8137.2022.487
The authors declare that they have no competing interests.
A.R., Y.L., and T.K.C. wrote the manuscript. H.Z., Y.X., X.C., and H.Z. contributed perspectives and conducted proofreading. D.X. and S.B.O. conceived the idea for the manuscript, guided the writing, and performed final editing of the manuscript. All authors read and approved the final version of the manuscript.
Funds:  This work was supported by the Early Career Scheme (ECS) 2022/23 (CUHK 24110822) from the Research Grants Council of Hong Kong, as well as the Direct Grant for Research 2020/21 (2020.035), Project Impact Enhancement Fund (PIEF) (PIEF/Ph2/COVID/08), and Improvement on Competitiveness in Hiring New Faculties Funding Scheme from CUHK as well as the Centre for Cardiovascular Genomics and Medicine (CCGM) of the Lui Che Woo Institute of Innovative Medicine CUHK (to S.B.O.). A.R. is a CUHK Department of Medicine & Therapeutics (MEDT)-funded PhD student. Y.L. is a CUHK Vice-Chancellor’s PhD Scholarship holder
More Information
  • Large animal models of cardiac ischemia-reperfusion are critical for evaluation of the efficacy of cardioprotective interventions prior to clinical translation. Nonetheless, current cardioprotective strategies/interventions formulated in preclinical cardiovascular research are often limited to small animal models, which are not transferable or reproducible in large animal models due to different factors such as: (i) complex and varied features of human ischemic cardiac disease (ICD), which are challenging to mimic in animal models, (ii) significant differences in surgical techniques applied, and (iii) differences in cardiovascular anatomy and physiology between small versus large animals. This article highlights the advantages and disadvantages of different large animal models of preclinical cardiac ischemic reperfusion injury (IRI), as well as the different methods used to induce and assess IRI, and the obstacles faced in using large animals for translational research in the settings of cardiac IR.
  • The authors declare that they have no competing interests.
    A.R., Y.L., and T.K.C. wrote the manuscript. H.Z., Y.X., X.C., and H.Z. contributed perspectives and conducted proofreading. D.X. and S.B.O. conceived the idea for the manuscript, guided the writing, and performed final editing of the manuscript. All authors read and approved the final version of the manuscript.
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