Department of Biology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China
This study was supported by the start-up grant from "Top 100 Talents Program" of Sun Yat-sen University to JRY (50000-31131114) and General Program of National Natural Science Foundation of China to JRY (31671320)
Currently many facets of genetic information are ill-defined. In particular, how protein folding is genetically regulated has been a long-standing issue for genetics and protein biology. And a generic mechanistic model with supports of genomic data is still lacking. Recent technological advances have enabled much needed genome-wide experiments. While putting the effect of codon optimality on debate, these studies have supplied mounting evidence suggesting a role of mRNA structure in the regulation of protein folding by modulating translational elongation rate. In conjunctions with previous theories, this mechanistic model of protein folding guided by mRNA structure shall expand our understandings of genetic information and offer new insights into various biomedical puzzles.