Loss of behavioral stress response in blind cavefish reduces energy expenditure

Jiang-Hui Zhang; Rui Long; Yang-Yang Jing; Pan Zhang; Yuan Xu; Wei Xiong; Yan-Qiu Zhu; Yi-Ping Luo

doi:10.24272/j.issn.2095-8137.2022.354

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Jiang-Hui Zhang, Rui Long, Yang-Yang Jing, Pan Zhang, Yuan Xu, Wei Xiong, Yan-Qiu Zhu, Yi-Ping Luo. Loss of behavioral stress response in blind cavefish reduces energy expenditure. Zoological Research, 2023, 44(4): 678-692. doi: 10.24272/j.issn.2095-8137.2022.354

Citation:

Jiang-Hui Zhang, Rui Long, Yang-Yang Jing, Pan Zhang, Yuan Xu, Wei Xiong, Yan-Qiu Zhu, Yi-Ping Luo. Loss of behavioral stress response in blind cavefish reduces energy expenditure. Zoological Research, 2023, 44(4): 678-692. doi: 10.24272/j.issn.2095-8137.2022.354

Citation:

Jiang-Hui Zhang, Rui Long, Yang-Yang Jing, Pan Zhang, Yuan Xu, Wei Xiong, Yan-Qiu Zhu, Yi-Ping Luo. Loss of behavioral stress response in blind cavefish reduces energy expenditure. Zoological Research, 2023, 44(4): 678-692. doi: 10.24272/j.issn.2095-8137.2022.354

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Loss of behavioral stress response in blind cavefish reduces energy expenditure

doi: 10.24272/j.issn.2095-8137.2022.354

1.
Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, School of Life Sciences, Southwest University, Chongqing 400715, China

Data related to this paper have been deposited in Figshare: https://doi.org/10.6084/m9.figshare.20781154.v2.
Supplementary data to this article can be found online.
The authors declare that they have no competing interests.
J.H.Z. and Y.P.L. conceived the ideas and designed the methodology; J.H.Z., R.L., Y.Y.J., P.Z., Y.X., W.X., and Y.Q.Z. collected the data; J.H.Z. analyzed the data and drafted the manuscript. Y.P.L. critically reviewed the manuscript. All authors read and approved the final version of the manuscript.

Funds: This study was supported by the National Natural Science Foundation of China (32070438)

More Information

Corresponding author: E-mail: luoguo@swu.edu.cn
Received Date: 2023-03-03
Accepted Date: 2023-04-27

Published Online: 2023-04-28

Abstract

Abstract

The stress response is essential for animal self-defense and survival. However, species may exhibit stress response variation depending on their specific environmental and selection pressures. Blind cavefish dwell in cave environments, which differ markedly in stressors and resource availability compared to surface aquatic environments. However, whether blind cavefish exhibit differences in stress response as an adaptation to their cave environments remains unclear. Here, we investigated differences in stress response in six closely related Triplophysa species, including three blind cavefish (T. longibarbata, T. jiarongensis, and T. rosa) and three normal-sighted river fish (T. nasobarbatula, T. dongsaiensis, and T. bleekeri). Results showed that blind cavefish exhibited a range of distinct behavioral responses compared to sighted river fish, including greater levels of activity, shorter duration of freezing, absence of erratic movements or thrashing behavior, and opposite behavioral trends over time. Furthermore, the cavefish species demonstrated attenuated increases in metabolic rate in response to stressors related to novel environments. Cave-dwelling T. rosa also exhibited lower basal hypothalamic-pituitary-inter-renal (HPI) axis-related gene expression levels and stress hormone concentrations compared to river-dwelling T. bleekeri. These results suggest that blind cavefish may have lost their behavioral stress response, potentially mediated by a reduction in basal activity of the HPI axis, thus enabling the conservation of energy by reducing unnecessary expenditure in energy-limited caves.
- Cavefish,
- Stress responses,
- Behavior,
- Metabolic rate

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