Abstract: Tricodons on the messenger RNA nucleotide sequence decide the amino acid sequence of their encoded protein.However,the rate with which the mRNA is translated in ribosome depends on several parameters such as different synonymous codon usage,codonanticodon interactions,codon context and different secondary structures in mRNA.These parameters also affect cotranslational folding and assembly of protein structure.That suggests the existence of the correlation between the sequence and structure of mRNA and protein structure.