Abstract: Seven kinds of hair dye are selected to lay on the skins of NIH strain mouse.After being touched with the hair dyes 7 times during 23 days,the mouse bone marrow cells and testis cells are collected to observe the chromosomal aberrations.The results show that all kinds of hair dye can induce the chromosomal aberration of mouse bone marrow cells and the aberration types include break,fragment,ring and so on.The ratios of chromosomal aberrations induced by three kinds of hair dye are statistically significant higher than control and the powdery types are the highest.Four kinds of hair dye of the seven have been to studied the chromosomal aberrations of the male mouse germinal cells.All of them induce the chromosomal aberration of the germinal cells (the aberration types include fragment,monovalent,quadrivalent),and the aberration ratios are statistically significant higher and the instant-oxidative types are the highest.