幼年和老年人鼠学习中海马CA3区长时程突触增强的年龄特征

The Age Characteristics of the Long-Term Synaptic Potentiation in the CA3 Region of Hippocampus of the Young and The Aged Rats During The Learning

摘要: 研究发现幼年和老年大鼠在条件性饮水反应的建立、消退和再建立过程中，海马CA3区有习得性长时程突触增强（LTP）的形成、消退和再形成现象。在它们的形成和再形成以及每实验日训练作业后习得性LTP的发展上，幼年鼠明显快于老年鼠，而习得性LTP的消退，在两组间无明显差异。这既表明海马CA3区的习得性LTP具年龄特征，也为论证习得性LTP可能是学习和记忆的神经基础之一提供了新的证据。

Abstract: The learning-dependent long-term potentiation (LTP) in the hippocampal CA3 region of the young and aged rats all was changed obviously during the establishment,extinction and re-establishment of conditioned drink response.The velocity of establishment and development of the learning-dependent LTP in CA3 of the young rats is more than that of the aged rats.However there was nonsignificant differnece in the extinction of the learning-dependent LTP in CA3 of the young and the aged rats.These results not only showed that there was the age characteristics of the learning-dependent LTP in the CA3 region but also provided a evidence that the learning-dependent LTP might be one of the neural bases of learning and memory.