• 中文核心期刊要目总览
  • 中国科技核心期刊
  • 中国科学引文数据库（CSCD）
  • 中国科技论文与引文数据库（CSTPCD）
  • 中国学术期刊文摘数据库（CSAD）
  • 中国学术期刊（网络版）（CNKI）
  • 中文科技期刊数据库
  • 万方数据知识服务平台
  • 中国超星期刊域出版平台
  • 国家科技学术期刊开放平台
  • 荷兰文摘与引文数据库（SCOPUS）
  • 日本科学技术振兴机构数据库（JST）
高级检索
阮长耿, 奚晓东 等, 顾振纶. 1983: 烙铁头Trimeresurus mucrosquamatus蛇毒对血小板的活化作用. 动物学研究, 4(3): 245-254.
引用本文: 阮长耿, 奚晓东 等, 顾振纶. 1983: 烙铁头Trimeresurus mucrosquamatus蛇毒对血小板的活化作用. 动物学研究, 4(3): 245-254.
shu
RUAN Chang-geng et al., GU Zhen-lun et al., WANG Wan-yu et al.. 1983. The Activation of Platelet Induced by the Venom of Trimeresurus Mucrosquamatus (From Hunan Province). Zoological Research, 4(3): 245-254.
Citation: RUAN Chang-geng et al., GU Zhen-lun et al., WANG Wan-yu et al.. 1983. The Activation of Platelet Induced by the Venom of Trimeresurus Mucrosquamatus (From Hunan Province). Zoological Research, 4(3): 245-254.
shu

烙铁头Trimeresurus mucrosquamatus蛇毒对血小板的活化作用

The Activation of Platelet Induced by the Venom of Trimeresurus Mucrosquamatus (From Hunan Province)

    摘要
  • 摘要: 烙铁头Trimeresurus mucrosquamatus蛇毒（TMV）可引起人和多种动物（狗、家兔、豚鼠）血小板的活化，发生聚集。血小板聚集强度与加入TMV的量有关。豚鼠血小板对TMV最为敏感，TMV引起豚鼠、家兔、狗和人的血小板聚集的最低剂量分别为0.6、12.5、2.0、2.0 μg/Ml。EDTA抑制而肝素不影响TMV对血小板的聚集作用。TMV的血小板聚集反应伴有5羟色胺的释放，引起家兔血小板5羟色胺最大释放（72%）的TMV剂量为100 μg/Ml。TMV还可以诱导血小板血栓恶烷A2的形成。阿斯匹林能阻断TMV诱导的血栓恶烷A2的生成，但并不抑制TMV引起的血小板聚集反应，提示TMV可能通过不依赖于血栓恶烷A2的途径活化。初步结果表明TMV是研究血小板生理机制的有用工具。

     

    Abstract: Trimeresurus Mucrosquamatus venom (TMV) induced the concentration-dependent aggregation of platelets of different species.The threshold concentrations of TMV inducing the platelet aggregation of human,rabbit,dog and Guinea pig were 2.0,12.5,2.0 and 0.6 μg/Ml respectively.EDTA interfered with the platelet aggregation by TMV,but heparin did not prevent the action of TMV.The platelet aggregation induced by TMV was accompanied by the release of serotonin (5-HT) from the challenged platelets.The concentration of TMV which induced the maxium release of 5-HT (72%) from rabbit platelets was 100 μg/Ml.The TMV also induced the formation of Thromboxane A2 (TXA2) of platelets.The inhibition of cyclo-oxygenase with apirin,which reduced and abolished the formation of TXA2,but did not suppress platelt aggregation induced by TMV.Thus,thromboxane-independent mechanisms should account for platelet activation with TMV.Our preliminary results shown that TMV is a good tool for studying the activation of platelets.

     

    • HTML全文
    • 参考文献(0)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回