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Acute effects of IL-1β on sodium current in cortical neurons of rats

QI Cui ZHANG Wei-Wei WANG Fei BAO Chao-Fei WANG Xin-Wei LI Xiao-Nan YU Xiao-Q

QI Cui, ZHANG Wei-Wei, WANG Fei, BAO Chao-Fei, WANG Xin-Wei, LI Xiao-Nan, YU Xiao-Q. Acute effects of IL-1β on sodium current in cortical neurons of rats. Zoological Research, 2011, 32(3): 323-328. doi: 10.3724/SP.J.1141.2011.03323
Citation: QI Cui, ZHANG Wei-Wei, WANG Fei, BAO Chao-Fei, WANG Xin-Wei, LI Xiao-Nan, YU Xiao-Q. Acute effects of IL-1β on sodium current in cortical neurons of rats. Zoological Research, 2011, 32(3): 323-328. doi: 10.3724/SP.J.1141.2011.03323

白介素1β对大鼠皮层神经元钠电流的急性作用

doi: 10.3724/SP.J.1141.2011.03323
基金项目: 河北省教育厅科学研究计划(Z2009109); 北京大学生物膜与膜生物工程国家重点实验室开放课题
详细信息
    作者简介:

    齐翠:齐 翠

  • 中图分类号: Q424; Q426; R338.2

Acute effects of IL-1β on sodium current in cortical neurons of rats

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    Author Bio:

    QI Cui

  • 摘要: 白介素1β(Interleukin-1β, IL-1β)是重要的促炎细胞因子, 在多种中枢神经系统的损伤和疾病过程中发挥关键作用。电压门控的钠通道是神经元中最重要的离子通道之一, 是产生再生性动作电位的基础, 决定了神经元的兴奋性等电学性质, 也与多种中枢疾病过程相关。然而, 现在还没有直接关于IL-1β与中枢钠通道的相互关系的研究。在该研究中, 使用全细胞膜片钳记录测定了IL-1β对培养的皮层神经元钠电流的急性作用, 并分析了由此对动作电位的影响。结果显示, IL-1β对钠电流幅度只有较小的抑制, 而显著降低钠通道的半激活电压, 不改变激活的斜率因子和失活性质, 这个作用引起动作电位阈值显著降低。这些结果提示在损伤和疾病过程中, 快速释放的IL-1β可能会增加神经元兴奋性, 从而恶化神经损伤过程。
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出版历程
  • 收稿日期:  2010-09-25
  • 修回日期:  2011-01-28
  • 刊出日期:  2011-06-22

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