Abstract: The effect of abdomnoinjection prostaglandin E1(PGE1) on antral myoelectric activity was investigated in 30 Wistar rats chronically implanted with Ag/AgCl bipolar electrode on the serosal surface of antrum.It was found that PGE1 could 1) decrease the amplitude of slow wave;2) cause biphasic changes of fast wave,usually with enhancement before giving way to inhibition;3) cause diarrhea.The inhibitory action of PGE1 on slow wave and fast wave might be not mediated via adrenergic α and β receptor,and the excitatory action of PGE1 on fast wave was probably mediated via cholinergic M receptor.