昆明小鼠物体识别模型的建立及其在检测化学药物对记忆损伤中的应用

Founding of Object Recognition Learning Paradigm in KM Mice and Its Application in Detecting Memory Impaired Properties of Compounds

摘要: 本研究的主要目的是建立昆明鼠物体识别模型并评价该模型在安全药理学研究中的潜在应用价值。我们研究了昆明鼠物体识别记忆随时间而削弱的特性，在训练结束后4小时或1小时，检测了昆明鼠的物体识别记忆，并评价了东莨胆碱对昆明鼠物体识别记忆的影响。结果表明：昆明鼠在训练结束后1小时记忆保持良好，可以建立物体识别模型；东莨胆碱损伤了昆明鼠的物体识别记忆。昆明鼠物体识别模型具有简单、快速、可靠等特点，可以在安全药理学研究中用来检测化学药物对记忆的损伤。

Abstract: The aim of the present study was to found the object recognition learning paradigm in KM mice and evaluate the potential usefulness of the object recognition learning paradigm in safety pharmacology. The time dependent decay of object recognition memory was characterized in KM mice. Memory retention was tested 4 h or 1 h after training in KM mice. The impairment of scopolamine on the object recognition memory was assessed in KM mice. Results show that the object recognition task can easily be performed and scopolamine impairs the object recognition memory in KM mice. The object recognition task in KM mice, which is simple, rapid, and reliable, should be of great use in safety pharmacology to detect amnesic properties of new compounds.