Abstract: Four Yorkshire-Erhualian growing gilts implanted with a chronic jugular vein catheter were used to investigate the short-term effect of cimaterol (CIM) on serum metabolite concentration,GPT activity and neuroendocrine hormone level.When the gilts were treated with 1 μg/g CIM,SUN decreased significantly and maintained low level in the 5 days observed,while serum FFA maintained a high level.Serum GPT activity and β-endorphin concentration increased too.SS concentration significantly decreased and gastrin level elevated.The results showed that CIM significantly improved protein anabolic metabolism and increased nitrogen deposition in gilts,while significantly stimulated fat degradation through altering SS and β-endorphin levels.