海马结构与大白鼠避暗行为的学习和记忆IV. 微量秋水仙素注入海马结构各部的影响

The hippocampal formation and learning and memory of dark avoidance behavior in rats IV. effects of colchicine microinjected into various parts of hippocampal formation

摘要: 在成年的雌性Wister大白鼠双侧海马结构的各部,地区分别注以0.5微升含3微克秋水仙素的生理盐水,观察能否影响避暗行为的学习和记忆,并作相关的组织学检查,结果表明:双侧背部或后部背侧的齿状回颗粒细胞的损毁, 对大白鼠避暗行为的学习和记忆无明显的影响:若损毁Krieg大白鼠脑图谱的H6.0毫米水平面腹侧的齿状回颗粒细胞,则非常显著地削弱(但未能完全阻断)避免暗行为的学习和记忆.

Abstract: In this experiment, 3µg of colchicine were respectively injected into varous parts of the bilateral hippocampal fromation in adult Wistar's female rats. We observed whether it could influence the learning and memory of dark avoidance behavior, and examined correlative histology. These results show that the rats having been injured the granual cells of bilateral dorsal or posterior dorsal parts of dentate gyrus can perform the learning and memory of the dark avoidance behavior without any impairment, but injured at ventral part from H6.0mm horizontal plane in rat's brain stereotaxic atlas by Krieg, they perform it with strikingly weakened, however don't block it entirely.