核糖体失活蛋白抗HIV-1作用的研究进展
Progress in Anti-HIV-1 Actions of Ribosome Inactivating Proteins
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摘要: 核糖体失活蛋白(RIPs)抗HIV-1活性研究已有十几年的历史。RIPs类化合物代表了抗HIV/AIDS天然产物或先导化合物发展的一个重要方向。本文从介绍RIPs的酶活性及其抗HIV-1活性入手，对RIPs抗HIV-1的可能机制，从与RIPs酶活性的关系、诱导HIV-1感染细胞的凋亡及相应的信号转导、诱发活性氧的产生，以及对HIV-1整合酶的抑制作用等几个方面做了较详尽的阐述，并对RIPs的结构修饰和抗HIV-1构效关系进行了综述。对RIPs类化合物在抗病毒领域进行深入而系统地研究，能拓宽其在抗HIV/AIDS临床上的进一步应用。Abstract: The anti-HIV-1 research history of ribosome inactivating proteins (RIPs) can be traced back to McGrath's work in 1989. They are important representatives, which guide further research, of natural anti-HIV products or leading compounds. The enzymatic activities and anti-HIV-1 actions of RIPs were introduced initially in this paper, followed by a detailed discussion about the potential anti-HIV-1 mechanisms. The discussion mainly focuses on the relationships with anti-HIV-1 enzymatic activities, induction of apoptosis of HIV-1 infected cells and responding cell signaling, the production of reactive oxygen species, the HIV-1 integrase inhibition effect. The anti-HIV-1 structure-functional relationship of RIPs and the structural modifications were also covered. Systemic and intensive studies of RIPs' antiviral actions will increase their possibility as clinical anti-HIV/AIDS agents.
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