Abstract: Using indirect immunofluorescent method,we have studied the localization of epidermal growth factor receptor (EGFR) in mouse fetus.Specific fluorescent was found on the cell membrane of various tissues at the different development stages of mouse fetus,such as the nasal mucous membrane epithelial cells in the 14.5th to 19th days,the glossal epithelial cells on day 16,the vascular epithelial cells of aorta descendens on day 18.5,the stomachal mucous membrane epithelium between the 17th and 18th days,the duodenal epithelial cells between days 17.5 and 18,the rectal mucous membrane epithelial cells and the vesical transitional epithelium between the 15.5th and 16th days and in the hepatic cells in the 14.5th to 19th days.EGFR positive cells were also observed in the anal tube,primodium of eye lid,adenohypophysial glandular epithelium,sublingual gland,adrenal medulla,ovarial medulla,submaxillary gland,glandula accessoria and pancreas islet cells.