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Blockage of glucocorticoid receptors during memory acquisition, retrieval and reconsolidation prevents the expression of morphine-induced conditioned place preferences in mice

Yao-Dong FAN Hai-Chen NIU Tanzeel Huma Ling LI Gui-Mei WANG Li-Qi XU He REN Yuan-Ye MA Hua-Lin YU

Yao-Dong FAN, Hai-Chen NIU, Tanzeel Huma, Ling LI, Gui-Mei WANG, Li-Qi XU, He REN, Yuan-Ye MA, Hua-Lin YU. Blockage of glucocorticoid receptors during memory acquisition, retrieval and reconsolidation prevents the expression of morphine-induced conditioned place preferences in mice. Zoological Research, 2013, 34(E1): 5626-E. doi: 10.3724/SP.J.1141.2013.E01E26
Citation: Yao-Dong FAN, Hai-Chen NIU, Tanzeel Huma, Ling LI, Gui-Mei WANG, Li-Qi XU, He REN, Yuan-Ye MA, Hua-Lin YU. Blockage of glucocorticoid receptors during memory acquisition, retrieval and reconsolidation prevents the expression of morphine-induced conditioned place preferences in mice. Zoological Research, 2013, 34(E1): 5626-E. doi: 10.3724/SP.J.1141.2013.E01E26

Blockage of glucocorticoid receptors during memory acquisition, retrieval and reconsolidation prevents the expression of morphine-induced conditioned place preferences in mice

doi: 10.3724/SP.J.1141.2013.E01E26
详细信息
    通讯作者:

    Yuan-Ye MA, Hua-Lin YU

Blockage of glucocorticoid receptors during memory acquisition, retrieval and reconsolidation prevents the expression of morphine-induced conditioned place preferences in mice

  • 摘要: Association between the reward caused by consuming drugs and the context in which they are consumed is essential in the formation of morphine-induced conditioned place preference (CPP). Glucocorticoid receptor (GRs) activation in different regions of the brain affects reward-based reinforcement and memory processing. A wide array of studies have demonstrated that blockage of GRs in some brain areas can have an effect on reward-related memory; however, to date there have been no systematic studies about the involvement of glucocorticoids (GCs) in morphine-related reward memory. Here, we used the GR antagonist RU38486 to investigate how GRs blockage affects the sensitization and CPP behavior during different phases of reward memory included acquisition, retrieval and reconsolidation. Interestingly, our results showed RU38486 has the ability to impair the acquisition, retrieval and reconsolidation of reward-based memory in CPP and sensitization behavior. But RU38486 by itself cannot induce CPP or conditioned place aversion (CPA) behavior. Our data provide a much more complete picture of the potential effects that glucocorticoids have on the reward memory of different phases and inhibit the sensitization behavior.
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  • 收稿日期:  2012-06-06
  • 修回日期:  2012-10-30
  • 刊出日期:  2013-02-08

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