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Current progress and future direction in the biology of ovarian germ stem cells in mammals

LI Chao-Hui GUO Kun ZHENG Ping

LI Chao-Hui, GUO Kun, ZHENG Ping. Current progress and future direction in the biology of ovarian germ stem cells in mammals. Zoological Research, 2012, 33(6): 586-590. doi: 10.3724/SP.J.1141.2012.06586
Citation: LI Chao-Hui, GUO Kun, ZHENG Ping. Current progress and future direction in the biology of ovarian germ stem cells in mammals. Zoological Research, 2012, 33(6): 586-590. doi: 10.3724/SP.J.1141.2012.06586

哺乳动物卵巢生殖干细胞研究的现状与未来

doi: 10.3724/SP.J.1141.2012.06586
基金项目: 中国科学院昆明动物研究所遗传资源与进化国家重点实验室2012开放课题(GREKF12-8)
详细信息
  • 中图分类号: Q915.87; Q954.43+2

Current progress and future direction in the biology of ovarian germ stem cells in mammals

  • 摘要: 哺乳动物卵巢中是否存在卵细胞再生(neo-oogenesis)及卵巢生殖干细胞一直是生殖生物学领域的争议热点之一.传统观点认为哺乳动物雌性个体出生后不再有新的卵细胞生成, 即个体出生时生殖细胞已发育到原始卵泡(primordial follicle)阶段, 停留在第一次减数分裂前期的双线期(diplotene), 之后卵泡池中的配子或凋亡, 或重新启动发育, 没有生殖干细胞通过再生来产生新的卵子补充到卵泡库中.然而, 近年的研究结果发现, 小鼠和人卵巢中可以分离出一类生殖细胞, 它们在体外培养条件下具有增殖和自我更新的能力, 移植入卵巢后可以分化形成有功能的卵细胞, 从而挑战了这一传统理念.但是, 生理条件下卵巢中是否也存在这样一类生殖干细胞, 其生理功能如何.该文就此方面的研究现状和未来发展进行评述.
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出版历程
  • 收稿日期:  2012-09-21
  • 修回日期:  2012-11-18
  • 刊出日期:  2012-12-08

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