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Establishment of tree shrew chronic morphine dependent model

SUN Yong-Mei YANG Jian-Zhen SUN Hua-Ying MA Yuan-Ye WANG Jian-Hong

SUN Yong-Mei, YANG Jian-Zhen, SUN Hua-Ying, MA Yuan-Ye, WANG Jian-Hong. Establishment of tree shrew chronic morphine dependent model. Zoological Research, 2012, 33(1): 14-18. doi: 10.3724/SP.J.1141.2012.01014
Citation: SUN Yong-Mei, YANG Jian-Zhen, SUN Hua-Ying, MA Yuan-Ye, WANG Jian-Hong. Establishment of tree shrew chronic morphine dependent model. Zoological Research, 2012, 33(1): 14-18. doi: 10.3724/SP.J.1141.2012.01014

慢性吗啡依赖树鼩模型的建立

doi: 10.3724/SP.J.1141.2012.01014
基金项目: “973”项目((2011CB707800); 中国科学院知识创新工程重要方向项目(KSCX2-EW-R-11)
详细信息
  • 中图分类号: Q959.832; Q95-33; Q189

Establishment of tree shrew chronic morphine dependent model

  • 摘要: 吗啡是一种有效的镇痛药, 但易使动物产生耐受性和成瘾性。在该实验中, 中缅树鼩 (Tupaia belangerichinensis)连续7 d, 每天接受三次肌肉注射递增剂量(5、10、15、20 mg/kg 体重)吗啡后对吗啡产生耐受和依赖; 吗啡注射完成后, 腹腔注射纳洛酮(1.25 mg/kg 体重)催瘾, 可诱导其条件性位置厌恶(conditioned place aversion, CPA)及相应吗啡戒断症状的出现。该结果提示树鼩慢性吗啡依赖模型的建立可用于研究吗啡依赖和耐受的生物学机制,以及减轻戒断症状药物的筛选。
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出版历程
  • 收稿日期:  2011-12-19
  • 修回日期:  2012-01-05
  • 刊出日期:  2012-02-22

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