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Impairment effects of tail suspension stress on spatial memory and its reversal learning in mice

WANG Xiao-Qin WANG Gong-Wu DUAN Qiu-Yan TENG Shi-Tong

WANG Xiao-Qin, WANG Gong-Wu, DUAN Qiu-Yan, TENG Shi-Tong. Impairment effects of tail suspension stress on spatial memory and its reversal learning in mice. Zoological Research, 2011, 32(4): 428-434. doi: 10.3724/SP.J.1141.2011.04428
Citation: WANG Xiao-Qin, WANG Gong-Wu, DUAN Qiu-Yan, TENG Shi-Tong. Impairment effects of tail suspension stress on spatial memory and its reversal learning in mice. Zoological Research, 2011, 32(4): 428-434. doi: 10.3724/SP.J.1141.2011.04428

悬尾应激对小鼠空间记忆及其反转学习的损伤效应

doi: 10.3724/SP.J.1141.2011.04428
基金项目: 中国科学院“西部之光”人才培养计划项目(2008); 云南省运动人体科学实验教学示范中心建设项目(2009); 国家自然科学基金项目 (31060142)
详细信息
    作者简介:

    王晓琴(1978-),硕士,讲师,主要从事运动生理学和神经生物学研究;E-mail: xiaoqinwang2001@yahoo.com.cn

    通讯作者:

    王功伍

Impairment effects of tail suspension stress on spatial memory and its reversal learning in mice

More Information
    Author Bio:

    WANG Xiao-Qin,E-mail: xiaoqinwang2001@yahoo.com.cn

    Corresponding author: WANG Gong-Wu2
  • 摘要: 该文探讨了连续数天短时悬尾应激对小鼠十字迷宫空间记忆及其反转学习的作用。81只成年雄性昆明小鼠被分为4大组:绝对空间记忆获得组及巩固组; 相对空间记忆获得组及巩固组。每大组又分为悬尾组(每天训练前或训练后立即接受悬尾处理20 min)和对照组。结果表明, 在空间记忆训练初期, 各对照组和悬尾组动物正确反应率无明显差异, 均在机遇水平; 随着训练天数的增加, 对照组成绩显著提高, 当其正确反应率达到80%时, 悬尾组正确反应率仍处于或略高于机遇水平, 两组间差异显著(P < 0.01); 在反转学习中, 悬尾组正确反应率也显著低于对照组(P < 0.01)。这些表明,悬尾应激可显著损伤小鼠的空间记忆及其反转学习的获得和巩固, 其中相对空间记忆及其反转学习的巩固受损尤为严重。
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  • 收稿日期:  2011-05-31
  • 修回日期:  2011-06-28
  • 刊出日期:  2011-08-22

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