留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

Modeling postpartum depression in rats: theoretic and methodological issues

Ming LI Shinn-Yi CHOU

Ming LI, Shinn-Yi CHOU. Modeling postpartum depression in rats: theoretic and methodological issues. Zoological Research, 2016, 37(4): 229-236. doi: 10.13918/j.issn.2095-8137.2016.4.229
Citation: Ming LI, Shinn-Yi CHOU. Modeling postpartum depression in rats: theoretic and methodological issues. Zoological Research, 2016, 37(4): 229-236. doi: 10.13918/j.issn.2095-8137.2016.4.229

大鼠的产后抑郁造模:理论和方法学

doi: 10.13918/j.issn.2095-8137.2016.4.229
详细信息
    通讯作者:

    Ming LI

Modeling postpartum depression in rats: theoretic and methodological issues

Funds: The preparation of this review was partially supported by a grant from the National Institute of Mental Health (5R01MH097718-02), U.S.A.
More Information
    Corresponding author: Ming LI
  • 摘要: 产后期是指在分子、细胞、生理和行为水平发生一系列改变,为女性的母性行为表达做准备的一个阶段。这些正常适应性变化的改变或抑制会导致情绪、动机和认知能力调节的异常,引起产后精神障碍,比如产后抑郁。尽管这种疾病发病率高,对母亲和孩子不利,但是其病因和相关的神经生物学机制仍然知之甚少,部分原因是由于缺乏适当的动物模型。近几十年来,已经有一些在大鼠上的尝试性研究来模拟产后抑郁。在本文中,我们首先描述了产后抑郁症的临床症状,并讨论已知的危险因素,包括遗传和环境方面。此后,我们讨论了多个已经建立的大鼠模型和这些尝试中获得的知识,而这些模型涉猎了产后抑郁的多个方面。在此过程中,我们关注每一次研究背后的理论和实现自己目标的方法。最后,我们提出了几个可研究领域,并为未来的发展方向提出建议。
  • [1] Andersson L, Sundström-Poromaa I, Wulff M, Åström M, Bixo M. 2006. Depression and anxiety during pregnancy and six months postpartum: a follow-up study. Acta Obstetricia et Gynecologica Scandinavica, 85(8): 937-944.
    [2] Beck CT. 2006. Postpartum depression: it isn't just the blues. The American Journal of Nursing, 106(5): 40-50; quiz 50-41.
    [3] Bifulco A, Brown GW, Moran P, Ball C, Campbell C. 1998. Predicting depression in women: the role of past and present vulnerability. Psychological Medicine, 28(1): 39-50.
    [4] Bifulco A, Figueiredo B, Guedeney N, Gorman LL, Hayes S, Muzik M, Glatigny-Dallay E, Valoriani V, Kammerer MH, Henshaw CA. 2004. Maternal attachment style and depression associated with childbirth: preliminary results from a European and US cross-cultural study. The British Journal of Psychiatry, 184(Suppl 46): s31-s37.
    [5] Bloch M, Schmidt PJ, Danaceau M, Murphy J, Nieman L, Rubinow DR. 2000. Effects of gonadal steroids in women with a history of postpartum depression. The American Journal of Psychiatry, 157(6): 924-930.
    [6] Boccia ML, Razzoli M, Vadlamudi SP, Trumbull W, Caleffie C, Pedersen CA. 2007. Repeated long separations from pups produce depression-like behavior in rat mothers. Psychoneuroendocrinology, 32(1): 65-71.
    [7] Brummelte S, Galea LAM. 2010. Chronic corticosterone during pregnancy and postpartum affects maternal care, cell proliferation and depressive-like behavior in the dam. Hormones and Behavior, 58(5): 769-779.
    [8] Brummelte S, Pawluski JL, Galea LAM. 2006. High post-partum levels of corticosterone given to dams influence postnatal hippocampal cell proliferation and behavior of offspring: A model of post-partum stress and possible depression. Hormones and Behavior, 50(3): 370-382.
    [9] Cools R, Roberts AC, Robbins TW. 2008. Serotoninergic regulation of emotional and behavioural control processes. Trends in Cognitive Sciences, 12(1): 31-40.
    [10] Couto TC, Brancaglion MY, Alvim-Soares A, Moreira L, Garcia FD, Nicolato R, Aguiar RA, Leite HV, Correa H, 2015. Postpartum depression: A systematic review of the genetics involved. World journal of psychiatry, 5: 103-111.
    [11] Englisch S, Knopf U, Scharnholz B, Kuwilsky A, Deuschle M, Zink M. 2009. Duloxetine for major depressive episodes in the course of psychotic disorders: an observational clinical trial. Journal of Psychopharmacology, 23(8): 875-882.
    [12] Forty L, Jones L, Macgregor S, Caesar S, Cooper C, Hough A, Dean L, Dave S, Farmer A, McGuffin P, Brewster S, Craddock N, Jones I. 2006. Familiality of postpartum depression in unipolar disorder: results of a family study. The American Journal of Psychiatry, 163(9): 1549-1553.
    [13] Galea LAM, Wide JK, Barr AM. 2001. Estradiol alleviates depressive-like symptoms in a novel animal model of post-partum depression. Behavioural Brain Research, 122(1): 1-9.
    [14] Gavin NI, Gaynes BN, Lohr KN, Meltzer-Brody S, Gartlehner G, Swinson T. 2005. Perinatal depression: a systematic review of prevalence and incidence. Obstetrics & Gynecology, 106(5): 1071-1083.
    [15] Giurgescu C, Misra DP, Sealy-Jefferson S, Caldwell CH, Templin TN, Slaughter-Acey JC, Osypuk TL. 2015. The impact of neighborhood quality, perceived stress, and social support on depressive symptoms during pregnancy in African American women. Social Science & Medicine, 130: 172-180.
    [16] Graeff FG, Guimaraes FS, De Andrade TGCS, Deakin JFW. 1996. Role of 5-HT in stress, anxiety, and depression. Pharmacology Biochemistry and Behavior, 54(1): 129-141.
    [17] Henry JD, Rendell PG. 2007. A review of the impact of pregnancy on memory function. Journal of Clinical and Experimental Neuropsychology, 29(8): 793-803.
    [18] Hill RA, Klug M, Kiss Von Soly S, Binder MD, Hannan AJ, van den Buuse M. 2014. Sex-specific disruptions in spatial memory and anhedonia in a "two hit" rat model correspond with alterations in hippocampal brain-derived neurotrophic factor expression and signaling. Hippocampus, 24(10): 1197-1211.
    [19] Hillerer KM, Neumann ID, Slattery DA. 2012. From stress to postpartum mood and anxiety disorders: how chronic peripartum stress can impair maternal adaptations. Neuroendocrinology, 95(1): 22-38.
    [20] Hillerer KM, Reber SO, Neumann ID, Slattery DA. 2011. Exposure to chronic pregnancy stress reverses peripartum-associated adaptations: implications for postpartum anxiety and mood disorders. Endocrinology, 152(10): 3930-3940.
    [21] Jones I, Heron J, Blackmore ER, Craddock N. 2008. Incidence of hospitalization for postpartum psychotic and bipolar episodes. Archives of General Psychiatry, 65(3): 356.
    [22] Kendler KS, Thornton LM, Gardner CO. 2001. Genetic risk, number of previous depressive episodes, and stressful life events in predicting onset of major depression. The American Journal of Psychiatry, 158(4): 582-586.
    [23] Kurata A, Morinobu S, Fuchikami M, Yamamoto S, Yamawaki S. 2009. Maternal postpartum learned helplessness (LH) affects maternal care by dams and responses to the LH test in adolescent offspring. Hormones and Behavior, 56(1): 112-120.
    [24] Lemaire V, Billard JM, Dutar P, George O, Piazza PV, Epelbaum J, Le Moal M, Mayo W. 2006. Motherhood-induced memory improvement persists across lifespan in rats but is abolished by a gestational stress. European Journal of Neuroscience, 23(12): 3368-3374.
    [25] Lin YM, Ko HC, Chang FM, Yeh TL, Sun HS. 2009. Population-specific functional variant of the TPH2 gene 2755C>A polymorphism contributes risk association to major depression and anxiety in Chinese peripartum women. Archives of Women's Mental Health, 12(6): 401-408.
    [26] Lonstein JS. 2005. Reduced anxiety in postpartum rats requires recent physical interactions with pups, but is independent of suckling and peripheral sources of hormones. Hormones and Behavior, 47(3): 241-255.
    [27] Lonstein JS. 2007. Regulation of anxiety during the postpartum period. Frontiers in Neuroendocrinology, 28(2-3): 115-141.
    [28] Mahon PB, Payne JL, MacKinnon DF, Mondimore FM, Goes FS, Schweizer B, Jancic D, Consortium NGIBD, Bi GSC, Coryell WH, Holmans PA, Shi J, Knowles JA, Scheftner WA, Weissman MM, Levinson DF, DePaulo JR Jr, Zandi PP, Potash JB. 2009. Genome-wide linkage and follow-up association study of postpartum mood symptoms. The American Journal of Psychiatry, 166(11): 1229-1237.
    [29] Maier SF, Watkins LR. 2005. Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. Neuroscience & Biobehavioral Reviews, 29(4-5): 829-841.
    [30] Malberg JE, Duman RS. 2003. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology, 28(9): 1562-1571.
    [31] Navarre BM, Laggart JD, Craft RM. 2010. Anhedonia in postpartum rats. Physiology & Behavior, 99(1): 59-66.
    [32] Nemeroff CB. 2008. Understanding the pathophysiology of postpartum depression: implications for the development of novel treatments. Neuron, 59(2): 185-186.
    [33] Nephew BC, Bridges RS. 2011. Effects of chronic social stress during lactation on maternal behavior and growth in rats. Stress, 14(6): 677-684.
    [34] Nephew BC, Byrnes EM, Bridges RS. 2010. Vasopressin mediates enhanced offspring protection in multiparous rats. Neuropharmacology, 58(1): 102-106.
    [35] O'Hara MW, McCabe JE. 2013. Postpartum depression: current status and future directions. Annual Review of Clinical Psychology, 9(1): 379-407.
    [36] Parker KJ, Schatzberg AF, Lyons DM. 2003. Neuroendocrine aspects of hypercortisolism in major depression. Hormones and Behavior, 43(1): 60-66.
    [37] Pearlstein T. 2013. Use of psychotropic medication during pregnancy and the postpartum period. Women's Health, 9(6): 605-615.
    [38] Pearlstein T, Howard M, Salisbury A, Zlotnick C. 2009. Postpartum depression. American Journal of Obstetrics and Gynecology, 200(4): 357-364.
    [39] Schiller CE, O'Hara MW, Rubinow DR, Johnson AK. 2013. Estradiol modulates anhedonia and behavioral despair in rats and negative affect in a subgroup of women at high risk for postpartum depression. Physiology & Behavior, 119: 137-144.
    [40] Shirayama Y, Chen AC, Nakagawa S, Russell DS, Duman RS. 2002. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. The Journal of Neuroscience, 22(8): 3251-3261.
    [41] Slattery DA, Cryan JF. 2012. Using the rat forced swim test to assess antidepressant-like activity in rodents. Nature Protocols, 7(6): 1009-1014.
    [42] Smith JW, Seckl JR, Evans AT, Costall B, Smythe JW. 2004. Gestational stress induces post-partum depression-like behaviour and alters maternal care in rats. Psychoneuroendocrinology, 29(2): 227-244.
    [43] Valentine G, Dow A, Banasr M, Pittman B, Duman R. 2008. Differential effects of chronic antidepressant treatment on shuttle box escape deficits induced by uncontrollable stress. Psychopharmacology, 200(4): 585-596.
    [44] Williams JL. 1984. Influence of postpartum shock controllability on subsequent maternal behavior in rats. Animal Learning & Behavior, 12(2): 209-216.
    [45] Yim IS, Stapleton LRT, Guardino CM, Hahn-Holbrook J, Schetter CD. 2015. Biological and psychosocial predictors of postpartum depression: systematic review and call for integration. Annual Review of Clinical Psychology, 11(1): 99-137.
    [46] Yonkers KA, Blackwell KA, Glover J, Forray A. 2014. Antidepressant use in pregnant and postpartum women. Annual Review of Clinical Psychology, 10(1): 369-392.
  • [1] Xiao-Li Feng, He-Long Che, Xi Ning, Xue-Ying Ba, Juan-Li, Jing-Fang Zhang, Yun Wang, Zheng-Fei Hu, Xin-Tian Hu, Xiao-Feng Ren.  Direct sunlight exposure reduces hair cortisol levels in rhesus monkeys (Macaca mulatta), Zoological Research. doi: 10.24272/j.issn.2095-8137.2019.064
    [2] Ding CUI, Yuan ZHOU.  Stress-relevant social behaviors of middle-class male cynomolgus monkeys (Macaca fascicularis), Zoological Research. doi: 10.13918/j.issn.2095-8137.2015.6.337
    [3] Xun-Xun CHU, Joshua Dominic Rizak, Shang-Chuan YANG, Jian-Hong WANG, Yuan-Ye MA, Xin-Tian HU.  A natural model of behavioral depression in postpartum adult female cynomolgus monkeys (Macaca fascicularis), Zoological Research. doi: 10.11813/j.issn.0254-5853.2014.3.174
    [4] WANG Jing, ZHOU Qi-Xin, LÜ Long-Bao, XU Lin, YANG Yue-Xiong.  A depression model of social defeat etiology using tree shrews, Zoological Research. doi: 10.3724/SP.J.1141.2012.01092
    [5] BAI Yao, ZHANG Yu-Hui, ZHAI Li-Li, LI Xin-Yi, YANG Jun, HONG Yan-Yan.  Estrogen receptor expression and vitellogenin synthesis induced in hepatocytes of male frogs Rana chensinensis exposed to bisphenol A, Zoological Research. doi: 10.3724/SP.J.1141.2011.03317
    [6] WANG Jing, ZHOU Qi-Xin, TIAN Men, YANG Yue-Xiong, XU Lin.  Tree shrew models: A chronic social defeat model of depression and a one-trial captive conditioning model of learning and memory, Zoological Research. doi: 10.3724/SP.J.1141.2011.01024
    [7] GU Chao-Yang, AN Shu-Cheng.  Rat orbital frontal (orbital frontal cortex, OFC) GABA B receptor mechanisms in stress and depression, Zoological Research. doi: 10.3724/SP.J.1141.2011.03329
    [8] XIANG Zuo-Fu , *,  HUO Sheng XIAO WenMale Allocare in Rhinopithecus bieti at Xiaochangdu, Tibet: Is It Related to Energetic Stress?, Zoological Research. doi: 10.3724/SP.J.1141.2010.02189
    [9] LI Qing-jiao, AN Shu-cheng.  Involvement of Hippocampal NMDA Receptor and Nitric Oxide Synthase in Depression Induced by Chronic Unpredicted Mild Stress, Zoological Research. doi: 10.3724/SP.J.1141.2009.06653
    [10] ZHANG Feng, LI Fa-zeng.  Effect of Hypericum perforatum on Growth and Brain Monoamine Neurotransmitters in Stressed Rats, Zoological Research.
    [11] HE Feng-qin, ZHANG Ju-wu, SHI Jing, WANG Bo.  Changes of Estrogen in Serum and Estrogen Receptor β inthe Relevant Brain Regions Following Mating Behavior of the Male Mandarin Vole Microtus mandarinus, Zoological Research. doi: 10.3724/SP.J.1141.2008.05529
    [12] ZHAND Feng, LI Fa-zeng, *Effect of Albizia julibrissin on Growth and Brain Monoamine Neurotransmitters in Chronic-Stressed Rats, Zoological Research.
    [13] WANG Hui-chun, TAI Fa-dao, LIAN Yi.  Age-specific Changes in Estrogen Receptors α in Testis and Epididymis of Mandarin Voles (Microtus mandarinus), Zoological Research.
    [14] ZHOU Xian-qing, QIAO Xin.  Effects of Vitamin C Polyphosphate on Anti-heat Stress Ability in Mice, Zoological Research.
    [15] XIE Mei-na, ZHANG Cai-qiao, MI Yu-ling, ZENG Wei-dong.  Effects of Follicle-stimulating Hormone and Estrogen on Development of Embryonic Chicken Germ Cell in Vitro, Zoological Research.
    [16] YANG Ming, LI Qin-fen.  Main Neuroendocrine Responses of Mammals in Cold Stress, Zoological Research.
    [17] CHEN Zhong, WANG Ting, HUANG Li-ming, FANG Dai-nan.  Effects of GABA on the Heat Stress Broilers, Zoological Research.
    [18] ZHOU Xian-Qing, SUN Ru-Yong, NIU Cui-Juan.  The Effects of Stress on Aquatic Animal's Growth,Behavior and Physiological Activity, Zoological Research.
    [19] SHE Wei-ming.  Characterization of Cytoplasmic Estrogen Receptor in Chicken Oviduct, Zoological Research.
    [20] MA Yuan-ye, TIAN Yu-fen, CAI Jing-xia.  Studies of the Stress-Induced Analgesia in the Tree Shrew (Tupaia belangeri chinensis), Zoological Research.
  • 加载中
计量
  • 文章访问数:  957
  • HTML全文浏览量:  57
  • PDF下载量:  1614
  • 被引次数: 0
出版历程
  • 收稿日期:  2015-11-10
  • 修回日期:  2016-01-20
  • 刊出日期:  2016-07-18

目录

    /

    返回文章
    返回