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Body mass, energy budget and leptin of mice under stochastic food restriction and refeeding

Zhi-Jun ZHAO Wen-Tao WEI Ming-Zhen LI Jing CAO

Zhi-Jun ZHAO, Wen-Tao WEI, Ming-Zhen LI, Jing CAO. Body mass, energy budget and leptin of mice under stochastic food restriction and refeeding. Zoological Research, 2013, 34(6): 574-581. doi: 10.11813/j.issn.0254-5853.2013.6.0574
Citation: Zhi-Jun ZHAO, Wen-Tao WEI, Ming-Zhen LI, Jing CAO. Body mass, energy budget and leptin of mice under stochastic food restriction and refeeding. Zoological Research, 2013, 34(6): 574-581. doi: 10.11813/j.issn.0254-5853.2013.6.0574

随机限食和重喂食对小鼠体重、能量收支及瘦素的影响

doi: 10.11813/j.issn.0254-5853.2013.6.0574
基金项目: 国家自然科学基金(31070367、31270458)
详细信息
  • 中图分类号: Q493.8;Q494

Body mass, energy budget and leptin of mice under stochastic food restriction and refeeding

  • 摘要: 为阐明限食和重喂食(SFR-Re)诱导的体重“补偿性增长”生理机制,该文测定了SFR-Re驯化的KM小鼠能量摄入与支出、身体成分以及血清瘦素水平。结果显示,随机限食使体重显著降低,重喂食后体重增加至对照组水平。驯化结束后,SFR-Re驯化小鼠基础代谢率增加,产热降低,褐色脂肪组织(BAT)细胞色素c氧化酶(COX)活性和解偶联蛋白1(UCP1)水平显著降低,摄入能、消化率和脂肪重量均显著高于自由取食的对照组小鼠,但血清瘦素水平组间差异不显著。即在食物资源丰富的条件下,经历食物短缺的动物将增加能量摄入和消化吸收效率以及脂肪组织能量贮存,从而导致体重的“补偿性增长”,同时,血清瘦素可能在该过程中发挥重要作用。
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  • 收稿日期:  2013-03-05
  • 修回日期:  2013-05-26
  • 刊出日期:  2013-12-08

Body mass, energy budget and leptin of mice under stochastic food restriction and refeeding

doi: 10.11813/j.issn.0254-5853.2013.6.0574
    基金项目:  国家自然科学基金(31070367、31270458)
  • 中图分类号: Q493.8;Q494

摘要: 为阐明限食和重喂食(SFR-Re)诱导的体重“补偿性增长”生理机制,该文测定了SFR-Re驯化的KM小鼠能量摄入与支出、身体成分以及血清瘦素水平。结果显示,随机限食使体重显著降低,重喂食后体重增加至对照组水平。驯化结束后,SFR-Re驯化小鼠基础代谢率增加,产热降低,褐色脂肪组织(BAT)细胞色素c氧化酶(COX)活性和解偶联蛋白1(UCP1)水平显著降低,摄入能、消化率和脂肪重量均显著高于自由取食的对照组小鼠,但血清瘦素水平组间差异不显著。即在食物资源丰富的条件下,经历食物短缺的动物将增加能量摄入和消化吸收效率以及脂肪组织能量贮存,从而导致体重的“补偿性增长”,同时,血清瘦素可能在该过程中发挥重要作用。

English Abstract

赵志军, 魏文涛, 李明振, 曹静. 随机限食和重喂食对小鼠体重、能量收支及瘦素的影响[J]. 动物学研究, 2013, 34(6): 574-581. doi: 10.11813/j.issn.0254-5853.2013.6.0574
引用本文: 赵志军, 魏文涛, 李明振, 曹静. 随机限食和重喂食对小鼠体重、能量收支及瘦素的影响[J]. 动物学研究, 2013, 34(6): 574-581. doi: 10.11813/j.issn.0254-5853.2013.6.0574
Zhi-Jun ZHAO, Wen-Tao WEI, Ming-Zhen LI, Jing CAO. Body mass, energy budget and leptin of mice under stochastic food restriction and refeeding. Zoological Research, 2013, 34(6): 574-581. doi: 10.11813/j.issn.0254-5853.2013.6.0574
Citation: Zhi-Jun ZHAO, Wen-Tao WEI, Ming-Zhen LI, Jing CAO. Body mass, energy budget and leptin of mice under stochastic food restriction and refeeding. Zoological Research, 2013, 34(6): 574-581. doi: 10.11813/j.issn.0254-5853.2013.6.0574
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