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雷爱华, 庞伟, 张高红, 郑永唐. 2013: 平顶猴在HIV/AIDS 动物模型中的应用及研究进展. 动物学研究, 34(2): 77-88. DOI: 10.3724/SP.J.1141.2013.02077
引用本文: 雷爱华, 庞伟, 张高红, 郑永唐. 2013: 平顶猴在HIV/AIDS 动物模型中的应用及研究进展. 动物学研究, 34(2): 77-88. DOI: 10.3724/SP.J.1141.2013.02077
Ai-Hua LEI, Wei PANG, Gao-Hong ZHANG, Yong-Tang ZHENG. 2013. Use and research of pigtailed macaques in nonhuman primate HIV/AIDS models. Zoological Research, 34(2): 77-88. DOI: 10.3724/SP.J.1141.2013.02077
Citation: Ai-Hua LEI, Wei PANG, Gao-Hong ZHANG, Yong-Tang ZHENG. 2013. Use and research of pigtailed macaques in nonhuman primate HIV/AIDS models. Zoological Research, 34(2): 77-88. DOI: 10.3724/SP.J.1141.2013.02077

平顶猴在HIV/AIDS 动物模型中的应用及研究进展

Use and research of pigtailed macaques in nonhuman primate HIV/AIDS models

  • 摘要: 非人灵长类动物模型在HIV-1 致病机制研究以及抗AIDS 药物和疫苗研发中具有重要作用。由于缺乏HIV-1 直接感染的动物, SIV/SHIV 猕猴模型是目前AIDS 研究中应用最为广泛的动物模型。虽然SIV/SHIV 猕猴模型与人AIDS 具有一定的相似性, 但SIV/SHIV 与HIV-1 间的遗传差异较大, 致使SIV/SHIV 猕猴模型存在很多局限性。创建合适的非人灵长类动物模型仍然是HIV/AIDS 研究中的热点和难点。平顶猴是目前唯一可以被HIV-1 感染的旧大陆猴, 在HIV-1 静脉传播和性传播模型研究中具有许多优势。该文综述了SIV、HIV、SHIV 和HSIV 通过静脉和黏膜途径感染平顶猴的特征, 并简要介绍了病毒在平顶猴细胞中复制的分子机制以及建立平顶猴AIDS 模型的限制因素和前景。

     

    Abstract: Nonhuman primate animal models play an important role in studying HIV-1 pathogenesis, developing antiviral drugs and vaccines. Due to the lack of animals that can be directly infected with HIV-1, SIV/SHIV-infected macaques have been widely used in AIDS research. Although these models are somewhat similar to human AIDS, there are many limitations due to genetic differences between SIV/SHIV and HIV-1. Developing a suitable nonhuman primate animal model is still an important topic in HIV/AIDS research. The pigtailed macaque is the only primate in Old World monkeys that can be infected with HIV-1 and offer many benefits as HIV-1 intravenous and sexual transmission models. Here we reviewed the characteristics of pigtailed macaque models infected by SIV, HIV, SHIV, and HSIV via intravenous and mucosal routes. In addition, we briefly introduced the molecular mechanisms of viral replication in pigtailed macaque cells, and discussed the limitations and prospects of pigtailed macaque models in AIDS research.

     

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