留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

Effects of urethane on the response properties of visual cortical neurons in young adult and old cats

PENG Qing-Song ZHOU Jun SHI Xia-Ming HUA Guo-Peng HUA Tian-Miao

PENG Qing-Song, ZHOU Jun, SHI Xia-Ming, HUA Guo-Peng, HUA Tian-Miao. Effects of urethane on the response properties of visual cortical neurons in young adult and old cats. Zoological Research, 2011, 32(3): 337-342. doi: 10.3724/SP.J.1141.2011.03337
Citation: PENG Qing-Song, ZHOU Jun, SHI Xia-Ming, HUA Guo-Peng, HUA Tian-Miao. Effects of urethane on the response properties of visual cortical neurons in young adult and old cats. Zoological Research, 2011, 32(3): 337-342. doi: 10.3724/SP.J.1141.2011.03337

乌拉坦对青、老年猫视皮层神经元反应特性的影响(英文)

doi: 10.3724/SP.J.1141.2011.03337
详细信息
    作者简介:

    彭青松

    通讯作者:

    华田苗

  • 中图分类号: Q42; R338.8; Q954.671

Effects of urethane on the response properties of visual cortical neurons in young adult and old cats

Funds: Supported by Natural Science Foundation of Anhui Province (070413138) and the Key Research Foundation of Anhui Province Education Department (KJ2009A167)
More Information
    Author Bio:

    PENG Qing-Song,

    Corresponding author: HUA Tian-Miao
  • 摘要: 以前的电生理研究结果显示, 老年哺乳动物视皮层细胞的自发反应及对视觉刺激的诱发反应比青年动物的显著增加, 而对光栅刺激的方位和运动方向选择性却显著下降。然而, 这种视皮层细胞功能的老年性改变是否因青、老年猫细胞对不同麻醉水平的敏感性差异引起尚不清楚。为探讨该问题, 以常用的麻醉药——乌拉坦(Urethane)为实验对象, 通过改变其麻醉剂量分别记录青、老年猫初级视皮层细胞对不同方位和运动方向光栅刺激的调谐反应。研究结果显示, 在基础麻醉量的基础上, 累积增加50 mg和100 mg乌拉坦对青、老年猫视皮层细胞的自发反应和诱发反应以及对光栅刺激方位和运动方向的选择性不产生显著影响, 累积增加150 mg乌拉坦会导致青、老年猫视皮层细胞对视觉刺激的反应性下降, 但下降的幅度相似。以上研究结果表明, 不同剂量的乌拉坦对青、老年动物视皮层细胞的反应性具有相似的影响。
  • [1] Culley DJ, Baxter M, Yukhananov R, Crosby G. 2003. The memory effects of general anesthesia persist for weeks in young and aged rats
    [J]. Anesth Analg, 96: 1004-1009, table of contents.He L, Li X, Hua T, Bao P, Zhou Y. 2005. Degradation of response modulation of visual cortical cells in cats with chronic exposure to morphine [J]. Neurosci Lett, 384: 168-171.Hilton P, Dev VJ, Major E. 1986. Intravenous anaesthesia with propofol and alfentanil. The influence of age and weight [J]. Anaesthesia, 41: 640-643.Hua T, Li G, Tang C, Wang Z, Chang S. 2009. Enhanced adaptation of visual cortical cells to visual stimulation in aged cats [J]. Neurosci Lett, 451: 25-28.Hua T, Li X, He L, Zhou Y, Wang Y, Leventhal AG. 2006. Functional degradation of visual cortical cells in old cats [J]. Neurobiol Aging, 27: 155-162.Hua T, Bao P, Huang CB, Wang Z, Xu J, Zhou Y, Lu ZL. 2010. Perceptual learning improves contrast sensitivity of V1 neurons in cats [J]. Curr Biol, 20: 887-894.Larsson JE, Wahlstrom G. 1996. Age-dependent development of acute tolerance to propofol and its distribution in a pharmacokinetic compartment-independent rat model
    [J]. Acta Anaesthesiol Scand, 40: 734-740.Larsson JE, Wahlstrom G. 1998. The influence of age and administration rate on the brain sensitivity to propofol in rats [J]. Acta Anaesthesiol Scand, 42: 987-994.Mendelson JR, Wells EF. 2002. Age-related changes in the visual cortex [J]. Vision Res, 42: 695-703.Nadstawek J, Hausmann D, Bartsch A, Fodisch M, Stoeckel H. 1989. Return of motor and mental functions following enflurane-nitrous oxide anesthesia of 1.3 MAC in various age groups [J]. Anasth Intensivther Notfallmed, 24: 293-297.Nakahiro M, Yeh JZ, Brunner E, Narahashi T. 1989. General anesthetics modulate GABA receptor channel complex in rat dorsal root ganglion neurons [J]. Faseb J, 3: 1850-1854.Scheepstra GL, Booij LH, Rutten CL, Coenen LG. 1989. Propofol for induction and maintenance of anaesthesia: comparison between younger and older patients
    [J]. Br J Anaesth, 62: 54-60.Schmolesky MT, Wang Y, Pu M, Leventhal AG. 2000. Degradation of stimulus selectivity of visual cortical cells in senescent rhesus monkeys [J]. Nat Neurosci, 3: 384-390.Sebel PS, Ingram DA, Flynn PJ, Rutherfoord CF, Rogers H. 1986. Evoked potentials during isoflurane anaesthesia [J]. Br J Anaesth, 58: 580-585.Segal JB, Moo LR, Hart J, Jr. 2002. The effect of age on rate of functional recovery after intracarotid amobarbital injection [J]. Epilepsia, 43: 659-661.Shou T, Li X, Zhou Y, Hu B. 1996. Adaptation of visually evoked responses of relay cells in the dorsal lateral geniculate nucleus of the cat following prolonged exposure to drifting gratings [J]. Vis Neurosci, 13: 605-613.Tigwell DA, Sauter J. 1992. On the use of isofluorane as an anaesthetic for visual neurophysiology [J]. Exp Brain Res, 88: 224-228.Uhl RR, Squires KC, Bruce DL, Starr A. 1980. Effect of halothane anesthesia on the human cortical visual evoked response [J]. Anesthesiology, 53: 273-276.Villeneuve MY, Casanova C. 2003. On the use of isoflurane versus halothane in the study of visual response properties of single cells in the primary visual cortex
    [J]. J Neurosci Methods, 129: 19-31.
    [6]
     
  • 加载中
计量
  • 文章访问数:  2352
  • HTML全文浏览量:  230
  • PDF下载量:  1383
  • 被引次数: 0
出版历程
  • 收稿日期:  2010-10-19
  • 修回日期:  2011-02-17
  • 刊出日期:  2011-06-22

目录

    /

    返回文章
    返回