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Screening of spontaneous diabetes mellitus in middle- and old-aged cynomolgus monkey

WAN Yu-Ling ZHANG Yan-Chun PENG Bai-Lu LI Xue-Jia JI Fang JIN Li-Sha RAO Ju

WAN Yu-Ling, ZHANG Yan-Chun, PENG Bai-Lu, LI Xue-Jia, JI Fang, JIN Li-Sha, RAO Ju. Screening of spontaneous diabetes mellitus in middle- and old-aged cynomolgus monkey. Zoological Research, 2011, 32(3): 307-310. doi: 10.3724/SP.J.1141.2011.03307
Citation: WAN Yu-Ling, ZHANG Yan-Chun, PENG Bai-Lu, LI Xue-Jia, JI Fang, JIN Li-Sha, RAO Ju. Screening of spontaneous diabetes mellitus in middle- and old-aged cynomolgus monkey. Zoological Research, 2011, 32(3): 307-310. doi: 10.3724/SP.J.1141.2011.03307

中老年食蟹猴群体自发型糖尿病的筛选

doi: 10.3724/SP.J.1141.2011.03307
基金项目: 广州市科技计划项目 (2009A1-E051, 2010U1-E00811); 广东省林业局项目 (2009KJCX016); 国家”十二五”项目 (2011ZX09307-03-303)
详细信息
    作者简介:

    万玉玲(1979—), 女, 硕士, 研究方向:灵长类实验动物学; 张艳春(1984—), 女, 硕士, 研究方向:实验动物分子生物学

  • 中图分类号: Q959.848; R587.2;R-332

Screening of spontaneous diabetes mellitus in middle- and old-aged cynomolgus monkey

More Information
    Author Bio:

    WAN Yu-Ling

  • 摘要: 筛选440只中老年偏胖食蟹猴群体中自发糖尿病个体, 并探讨食蟹猴群体中糖尿病粗筛的方法。以调查基础血糖值为基础, 推断疑似糖尿病血糖值, 后经OGTT(口服糖耐量)和尿检结果验证该血糖值是否准确。结果显示中老年偏胖食蟹猴群体血糖值为(3.88±0.98) mmol/L, 其中56只食蟹猴血糖值大于5.0 mmol/L, 被初步定为糖尿病个体。这些个体全部糖耐量异常, 且36只(69.23%)出现尿糖阳性, 证明血糖值大于5.0 mmol/L可作为本群体食蟹猴糖尿病的粗筛标准。由于针对中老年偏胖食蟹猴群体, 患病率为12.72% (56/440), 高于我国糖尿病患病率(9.7%)。虽然该实验的糖尿病血糖指标并不适用于所有食蟹猴群体, 但是该筛选的流程简单快捷, 对动物损伤小, 可适用于大群体糖尿病的筛选。
  • [1] Cefalu WT, Wang ZQ, Bel1-Farrow A D, Collins J, Morgan T, Wagner JD. 2004, Caloric restriction and cardiovascular aging in cynomolgus monkeys(Macaca fascicu1aris): Metabolic, physiologic, and atherosclerotic measures from a 4-year intervention trial [J]. J Geronol, 59(10): 1007-1014.Hotta K, Funahashi T, Bodkin NL, Ortmeyer HK, Arita Y, Hansen BC, Matsuzawa Y. 2001. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys[J]. Diabetes, 50: 1126-1133.Kavanagh K, Fairbanks LA, Bailey JN, Jorgensen MJ, Wilson M, Zhang L, Rudle LL, Wagner JD. 2007. Characterization and heritability of obesity and associated risk factors in vervet monkeys[J]. Obesity, 15: 1666-1674.Leroith D, Taylor SI, Olefsky JM. 2004. Diabetes Mellitus: A Fundamental and Clinical Text[M]. Philadelphia: Lippincott Williams & Wilkins,1060-1066.Ramsey JJ, Laatsch JL, Kemnitz JW. 2000. Age and gender differences in body composition, energy expenditure, and glucoregulation of adult rhesus monkeys
    [J]. J Med Primatol 29:11-19.Slynkova K, Mannino DM, Martin GS, Morehead RS, Doherty DE. 2006. The role of body mass index and diabetes in the development of acute organ failure and subsequent mortality in an observational cohort[J]. Crit Care, 10(5): R137Tigno XT, Gerzanich G, Hansen BC. 2004. Age-related changes in metabolic parameters of nonhuman primates[J]. J Gerontol Ser A: Biol Sci Med Sci, 59: 1081-1088.Wagner JD, Cline JM, Shadoan MK, Bullock BC, Rankin SE, Cefalu WT. 2001. Naturally occurring and experimental diabetes in cynomolgus monkeys: A comparison of carbohydrate and lipid metabolism and islet pathology[J]. Toxicol Pathol, 29: 142-148. Wagner JE, Kavanagh K, Ward GM, Auerbach BJ, Harwood HJ Jr, Kaplan JR. 2006. Old world nonhuman primate model of type 2 diabetes mellitus
    [J]. ILAR J, 47(3): 259-71.Wang DP, Sui LH, Hong BQ, Sun YS, Li M, Li GJ, Fan X. 2007. Comparative study on values of blood physiol biochem between rhesus macaque and long-tailed macaque[J]. Chn J Comp Med, 17(7): 400-402, 434. 王冬平, 隋丽华, 洪宝庆, 孙岩松, 李慕, 李桂军, 凡秀. 2007.食蟹猴与猕猴血液生理和生化指标的比较. 中国比较医学杂志, 17(7): 400-402, 434.] Wang YJ, Ye HH, Shao JS. 2004. Discussion of rhesus monkey model of the spontaneous diabetes[J].Chn J Comp Med, 4(1): 13-15.[王艳静, 叶华虎, 邵军石. 2004. 猕猴自发性糖尿病动物模型的初步探讨. 中国比较医学杂志, 4(1): 13-15. ]Wen XL, Sun Y. 2003. Compare the capillary and venous blood glucose measured by blood glucose monitor [J]. Liaoning Pharm Clin Remed, 6(1): 38-39.
    [4] [文秀丽, 孙莹. 2003. 血糖仪测定毛细血管和静脉血糖的结果比较. 辽宁药物与临床, 6(1): 38-39.]Xu CL, Chen YM, Xu ZY, Lu Q, Xu Q, Shen YP, Su JF, Long Y. 2009. Establishment of cynomolgus monkeys diabetic models [J]. J Guangzhou Univ Trand Chn Med, 26(1): 91-94. [徐传磊, 陈艳明, 徐志勇, 卢奇, 徐勤, 沈逸萍, 苏俊芳, 龙艳. 2009. 建立食蟹猴糖尿病模型的研究. 广州中医药大学学报, 26(1): 91-94.]Yang WY, Lu JM, Weng JP, Jia WP, Ji LN, Xiao JZ, Shan ZY, Liu J, Tian HM, Ji QH, Zhu DL, Ge JP, Lin LX, Chen L, Guo XH, Zhao ZG, Li Q, Zhou ZG, Shan GL, He J. 2010. Prevalence of Diabetes among Men and Women in China [J]. N Engl J Med, 362: 1090-1101.Zeng XC, Ma J, Yan CM, Yao YS, Pan Y, Pan W, Zhou C, Jiang ZR, Pan XY. 2010. Diurnal variations of hematological and biochemical parameters in cynomolgus monkeys (Macaca fascicularis)[J] Chn J Comp Med, 20(6): 43-48. [曾宪成, 马璟, 杨琛懋, 姚呋舒, 潘严, 潘雯, 周超, 姜子睿, 潘学营. 2010. 食蟹猴血液学及血清生化指标日间节规律变化. 中国比较医学杂志, 20(6): 43-48.]Zhang LY, Zang L, Wang ZY, Song N. 2005. The establishment of hematology and biochemistry background information in Cynomolgus monkeys
    [J]. Sichuan J Physiol Sci, 27 (1): 39-40. [张六一, 张玲, 王振宇, 宋宁. 2005. 食蟹猴血液学和生化学指标数据背景资料的建立. 四川生理科学杂志, 27 (1): 39-40.]
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出版历程
  • 收稿日期:  2010-12-23
  • 修回日期:  2011-03-02
  • 刊出日期:  2011-06-22

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