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Expression status of diabetes-associated genes in middle and aged cynomolgus monkeys

ZHANG Xiu-Juan LI Xue-Jia XIA Ji-Liang YAN Sun-Xing JI Fang ZHANG Yan-Chun

ZHANG Xiu-Juan, LI Xue-Jia, XIA Ji-Liang, YAN Sun-Xing, JI Fang, ZHANG Yan-Chun. Expression status of diabetes-associated genes in middle and aged cynomolgus monkeys. Zoological Research, 2011, 32(3): 300-306. doi: 10.3724/SP.J.1141.2011.03300
Citation: ZHANG Xiu-Juan, LI Xue-Jia, XIA Ji-Liang, YAN Sun-Xing, JI Fang, ZHANG Yan-Chun. Expression status of diabetes-associated genes in middle and aged cynomolgus monkeys. Zoological Research, 2011, 32(3): 300-306. doi: 10.3724/SP.J.1141.2011.03300

中老年食蟹猴群中糖尿病相关基因的表达状态

doi: 10.3724/SP.J.1141.2011.03300
基金项目: 国家“十二五”科技支撑计划研究项目(2011ZX093073-024); 广州市重大科技专项项目(2010U1-E00811);广东省自然科学基金项目(10451026001004520)
详细信息
    作者简介:

    张秀娟(1979-), 女, 研究方向:灵长类实验动物学; E-mail: hallen6424@tom.com

  • 中图分类号: R587.1; Q959.848; R-332

Expression status of diabetes-associated genes in middle and aged cynomolgus monkeys

More Information
    Author Bio:

    ZHANG Xiu-Juan(1979-),E-mail: hallen6424@tom.com

  • 摘要: \该研究选择10岁以上健康中老年食蟹猴138只, 按空腹血糖值(FPG)将其分为低血糖组、血糖正常组和高血糖组。采用全自动血液生化仪分别检测各组血清中总胆固醇(TCHO)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)的水平变化; 采用荧光定量PCR分析食蟹猴外周血白细胞中37个糖尿病相关基因的mRNA表达情况。结果表明, 血清血脂水平HDL-C、LDL-C、TCHO和TG都与FPG分组无显著相关性(P>0.05), 而外周血白细胞中ACE、ACLY、PRKCB1、SLC2A4、SNAP23、VAPA、IGF2BP2、IFNG 8个基因的mRNA表达水平随FPG的升高而显著上调(P<0.05)。
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出版历程
  • 收稿日期:  2011-02-17
  • 修回日期:  2011-04-19
  • 刊出日期:  2011-06-22

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