尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!


Progress of non-human primate animal models of cancers

XIA Hou-Jun CHEN Ce-Shi

XIA Hou-Jun, CHEN Ce-Shi. Progress of non-human primate animal models of cancers. Zoological Research, 2011, 32(1): 70-80. doi: 10.3724/SP.J.1141.2011.01070
Citation: XIA Hou-Jun, CHEN Ce-Shi. Progress of non-human primate animal models of cancers. Zoological Research, 2011, 32(1): 70-80. doi: 10.3724/SP.J.1141.2011.01070


doi: 10.3724/SP.J.1141.2011.01070




  • 中图分类号: R-332; Q959.832

Progress of non-human primate animal models of cancers

Funds: This work was supported in part by a grant from Yunnan Province High-Profile Talent Project (云南省高端人才计划2010CI114), and grants from Chinese Academy of Sciences (Basic frontier project , KSCX2-EW-J-23)
More Information
    Author Bio:

    XIA Hou-Jun

    Corresponding author: CHEN Ce-Shi
  • 摘要: 癌症是人类第二大致死的疾病。将体外细胞模型获得的癌症研究结果向临床转化过程中, 动物活体实验是必不可少的一个环节。现在的肿瘤活体实验绝大部分采用啮齿类实验动物如小鼠和大鼠, 这是因为它们具有个体小、繁殖迅速、遗传背景清楚、转基因技术成熟等优势。但是啮齿类和人的亲缘关系比较远, 许多从啮齿类动物模型获得的研究结果不能在人体重现。非人灵长类动物在遗传进化、免疫、生理和代谢等诸多方面与人类高度近似, 理论上更加适合癌症研究。本文对现有的非人灵长类肿瘤研究做一综述, 主要集中介绍用化学和生物致癌剂在不同的非人灵长类动物诱导肿瘤的研究, 为将来用非人灵长类动物研究人类癌症奠定基础。
  • [1] Adamson RH. 1989. Induction of hepatocellular carcinoma in nonhuman primates by chemical carcinogens [J]. Cancer Detect Prev, 14(2): 215-219.Adamson RH, Cooper RW, O'Gara RW. 1970. Carcinogen-induced tumors in primitive primates [J]. J Natl Cancer Inst, 45(3):      555-559.Adamson RH, Correa P, Dalgard DW. 1973. Occurrence of a primary liver carcinoma in a Rhesus monkey fed aflatoxin B1 [J]. J Natl Cancer Inst, 50(2): 549-553.Adamson RH, Correa P, Sieber SM, McIntire KR, Dalgard DW. 1976. Carcinogenicity of aflatoxin B1 in rhesus monkeys: two additional cases of primary liver cancer [J]. J Natl Cancer Inst, 57(1): 67-78.Adamson RH, Krollkowski FJ, Correa P, Sieber SM and Dalgard DW. 1977. Carcinogenecity of 1-methyl-1-nitrosourea in nonhuman primates [J]. J Natl Cancer Inst, 59: 415-422.Adamson RH, Thorgeirsson UP, Snyderwine EG, Thorgeirsson SS, Reeves J, Dalgard DW, Takayama S, Sugimura T. 1990. Carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates: induction of tumors in three macaques [J]. Jpn J Cancer Res, 81(1): 10-14.Bailey J. 2009. An examination of chimpanzee use in human cancer research [J]. Altern Lab Anim, 37(4): 399-416.Baskin GB, Cremer KJ, Levy LS. 2001. Comparative pathobiology of HIV- and SIV-associated lymphoma [J]. AIDS Res Hum Retroviruses, 17(8): 745-751.Beniashvili DS. 1989. An overview of the world literature on spontaneous tumors in nonhuman primates [J]. J Med Primatol, 18(6): 423-437.Brack M. 1998. Spontaneous tumours in tree shrews (Tupaia belangeri): population studies [J]. J Comp Pathol, 118(4): 301-316.Brewer M, Baze W, Hill L, Utzinger U, Wharton JT, Follen M, Khan-Dawood F, Satterfield W. 2001a. Rhesus macaque model for ovarian cancer chemoprevention [J]. Comp Med, 51(5): 424-429.Brewer M, Utzinger U, Satterfield W, Hill L, Gershenson D, Bast R, Wharton JT, Richards-Kortum R, Follen M. 2001b. Biomarker modulation in a nonhuman rhesus primate model for ovarian cancer chemoprevention [J]. Cancer Epidemiol Biomarkers Prev, 10(8): 889-893.Bunton TE, Bacmeister CX. 1989. Diverticulosis and colonic leiomyosarcoma in an aged rhesus macaque [J]. Vet Pathol, 26(4): 351-352.Burdelya LG, Krivokrysenko VI, Tallant TC, Strom E, Gleiberman AS, Gupta D, Kurnasov OV, Fort FL, Osterman AL, Didonato JA, Feinstein E, Gudkov AV. 2008. An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models [J]. Science, 320(5873): 226-230.Chimpanzee Sequencing and Analysis Consortium. 2005. Initial sequence of the chimpanzee genome and comparison with the human genome [J]. Nature, 437(7055): 69-87.Cianciolo RE, Hubbard GB. 2005. A review of spontaneous neoplasia in baboons (Papio spp.) [J]. J Med Primatol, 34(2): 51-66.Cleary ML, Epstein MA, Finerty S, Dorfman RF, Bornkamm GW, Kirkwood JK, Morgan AJ, Sklar J. 1985. Individual tumors of multifocal EB virus-induced malignant lymphomas in tamarins arise from different B-cell clones [J]. Science, 228(4700): 722-724.Coggins CR. 2007. An updated review of inhalation studies with cigarette smoke in laboratory animals [J]. Int J Toxicol, 26(4): 331-338.Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R. 2009. Caloric restriction delays disease onset and mortality in rhesus monkeys [J]. Science, 325(5937): 201-204.Contente A, Zischler H, Einspanier A, Dobbelstein M. 2003. A promoter that acquired p53 responsiveness during primate evolution [J]. Cancer Res, 63(8): 1756-1758.Drill VA, Golway PL. 1978. Effect of ethynodiol diacetate with ethinyl estradiol on the mammary glands of rhesus monkeys: a preliminary report [J]. J Natl Cancer Inst, 60(5): 1169-1170.Drill VA, Martin DP, Hart ER, McConnell RG. 1974. Effect of oral contraceptives on the mammary glands of Rhesus monkeys: a preliminary report [J]. J Natl Cancer Inst, 52(5): 1655-1657.Duboise M, Guo J, Czajak S, Lee H, Veazey R, Desrosiers RC, Jung JU. 1998. A role for herpesvirus saimiri orf14 in transformation and persistent infection [J]. J Virol, 72(8): 6770-6776.Elliot OS, Elliot MW, Lisco H. 1966. Breast cancer in a tree shrew (Tupaia glis) [J]. Nature, 211(5053): 1105.Epstein MA, Morgan AJ, Finerty S, Randle BJ, Kirkwood JK. 1985. Protection of cottontop tamarins against Epstein-Barr virus-induced malignant lymphoma by a prototype subunit vaccine [J]. Nature, 318(6043): 287-289.Euler AR, Zurenko GE, Moe JB, Ulrich RG, Yagi Y. 1990. Evaluation of two monkey species (Macaca mulatta and Macaca fascicularis) as possible models for human Helicobacter pylori disease [J]. J Clin Microbiol, 28(10): 2285-2290.Feichtinger H, Putkonen P, Parravicini C, Li SL, Kaaya EE, Böttiger D, Biberfeld G, Biberfeld P. 1990. Malignant lymphomas in cynomolgus monkeys infected with simian immunodeficiency virus [J]. Am J Pathol, 137(6): 1311-1315.Fitzgerald J, de la Iglesia F, Goldenthal EI. 1982. Ten-year oral toxicity study with Norlestrin in rhesus monkeys [J]. J Toxicol Environ Health, 10(6): 879-896.Fleckenstein B, Daniel MD, Hunt RD, Werner J, Falk LA, Mulder C. 1978. Tumour induction with DNA of oncogenic primate herpesviruses [J]. Nature, 274(5666): 57-59.Fujimoto Y, Hampton LL, Luo LD, Wirth PJ, Thorgeirsson SS. 1992. Low frequency of p53 gene mutation in tumors induced by aflatoxin B1 in nonhuman primates [J]. Cancer Res, 52(4):    1044-1046. Geil RG, Lamar JK. 1977. FDA studies of estrogen, progestogens, and estrogen/progestogen combinations in the dog and monkey [J]. J Toxicol Environ Health, 3(1-2): 179-193.Geschickter CF, Hartman CG. 1959. Mammary response to prolonged estrogenic stimulation in the monkey [J]. Cancer, 12(4): 767-781.Habis A, Baskin GB, Murphey-Corb M, Levy LS. 1999. Simian AIDS-associated lymphoma in rhesus and cynomolgus monkeys recapitulates the primary pathobiological features of AIDS-associated non-Hodgkin’s lymphoma [J]. AIDS Res Hum Retroviruses, 15(15): 1389-1398.Hassan R, Ebel W, Routhier EL, Patel R, Kline JB, Zhang J, Chao Q, Jacob S, Turchin H, Gibbs L, Phillips MD, Mudali S, Iacobuzio-Donahue C, Jaffee EM, Moreno M, Pastan I, Sass PM, Nicolaides NC, Grasso L. 2007. Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin [J]. Cancer Immun, 7: 20.Hazell SL, Eichberg JW, Lee DR, Alpert L, Evans DG, Evans DJ Jr, Graham DY. 1992. Selection of the chimpanzee over the baboon as a model for Helicobacter pylori infection [J]. Gastroenterology, 103(3): 848-854.Hofmann W, Möller P, Schwaier A, Flügel RM, Zöller L, Darai G. 1981. Malignant tumours in Tupaia (tree shrew). J Med Primatol, 10(2-3): 155-163.Huang R, Cheng SJ. 2002. Review of spontaneous tumors in non-human primates [J]. Acta Laboratorium Animalis Scientia Sini, 10: 123-128. (in Chinese) Hunt RD, Meléndez LV, García FG, Trum BF. 1972. Pathologic features of Herpesvirus ateles lymphoma in cotton-topped marmosets (Saguinus oedipus) [J]. J Natl Cancer Inst, 49(6): 1631-1639.Isaksson E, Wang H, Sahlin L, von Schoultz B, Cline JM, von Schoultz E. 2003. Effects of long-term HRT and tamoxifen on the expression of progesterone receptors A and B in breast tissue from surgically postmenopausal cynomolgus macaques [J]. Breast Cancer Res Treat, 79(2): 233-239.Isaksson E, Wang H, Sahlin L, von Schoultz B, Masironi B, von Schoultz E, Cline JM. 2002. Expression of estrogen receptors (alpha, beta) and insulin-like growth factor-I in breast tissue from surgically postmenopausal cynomolgus macaques after long-term treatment with HRT and tamoxifen [J]. Breast, 11(4): 295-300.Jaikumar S, Zhuang Z, Mannan P, Vortmeyer AO, Furuta M, Dickerman R, Bedanova J, Lonser RR, Walbridge S, Weil RJ, Lobanenkov VV, Oldfield EH, Pack SD. 2007. Interspecies comparative genomic hybridization (I-CGH): a new twist to study animal tumor models [J]. Cell Cycle, 6(7): 836-842. Jayo MJ, Jayo JM, Jerome CP, Krugner-Higby L, Reynolds GD. 1988. Maxillo-orbital lymphoma (Burkitt’s-type) in an infant Macaca fascicularis [J]. Lab Anim Sci, 38(6): 722-726.Kapetanovic IM, Muzzio M, Hu SC, Crowell JA, Rajewski RA, Haslam JL, Jong L, McCormick DL. 2010. Pharmacokinetics and enhanced bioavailability of candidate cancer preventative agent, SR13668 in dogs and monkeys [J]. Cancer Chemother Pharmacol, 65(6): 1109-1116. Kim JJ, Yang JS, Dang K, Manson KH, Weiner DB. 2001. Engineering enhancement of immune responses to DNA-based vaccines in a prostate cancer model in rhesus macaques through the use of cytokine gene adjuvants [J]. Clin Cancer Res, 7: 882s-889s.Knappe A, Feldmann G, Dittmer U, Meinl E, Nisslein T, Wittmann S, Mätz-Rensing K, Kirchner T, Bodemer W, Fickenscher H. 2000. Herpesvirus saimiri-transformed macaque T cells are tolerated and do not cause lymphoma after autologous reinfusion [J]. Blood, 95(10): 3256-3261.Knappe A, Thurau M, Niphuis H, Hiller C, Wittmann S, Kuhn EM, Rosenwirth B, Fleckenstein B, Heeney J, Fickenscher H. 1998. T-cell lymphoma caused by herpesvirus saimiri C488 independently of ie14/vsag, a viral gene with superantigen homology [J]. J Virol, 72(4): 3469-3471.Lapis K, Zalatnai A, Timár F, Thorgeirsson UP. 1995. Quantitative evaluation of lysozyme- and CD68-positive Kupffer cells in diethylnitrosamine-induced hepatocellular carcinomas in monkeys [J]. Carcinogenesis, 16(12): 3083-3085.Li Y, Qin X, Cui J, Dai Z, Kang X, Yue H, Zhang Y, Su J, Cao J, Ou C, Yang C, Duan X, Yue H, Liu Y. 2008. Proteome analysis of aflatoxin B1-induced hepatocarcinogenesis in tree shrew (Tupaia belangeri chinensis) and functional identification of candidate protein peroxiredoxin II [J]. Proteomics, 8(7): 1490-1501. Li Y, Su J, Qin L, Egner PA, Wang J, Groopman JD, Kensler TW, Roebuck BD. 2000. Reduction of aflatoxin B(1) adduct biomarkers by oltipraz in the tree shrew (Tupaia belangeri chinensis) [J]. Cancer Lett, 154(1): 79-83.Li Y, Wan DF, Su JJ, Cao J, Ou C, Qiu XK, Ban KC, Yang C, Qin LL, Luo D, Yue HF, Zhang LS, Gu JR. 2004. Differential expression of genes during aflatoxin B(1)-induced hepatocarcinogenesis in tree shrews [J]. World J Gastroenterol, 10(4): 497-504.Lillie MA, Ambrus CM, Pickren JW, Akhter S, Islam A, Ambrus JL. 2004. Breast cancer in intraductal carcinogen-treated non-human primates [J]. J Med, 35(1-6): 271-275.Liu H, Merrell DS, Semino-Mora C, Goldman M, Rahman A, Mog S, Dubois A. 2009. Diet synergistically affects Helicobacter pylori-induced gastric carcinogenesis in nonhuman primates [J]. Gastroenterology, 137(4): 1367-1379. Long HM, Parsonage G, Fox CP, Lee SP. 2010. Immunotherapy for Epstein-Barr virus-associated malignancies [J]. Drug News Perspect, 23(4): 221-228.Ma BB, Chan AT. 2009. Infection and cancer: biology, therapeutics and prevention [J]. Future Oncol, 5(2): 149-151.Martin, R.D. 1990. Primate Origins and Evolution: A Phylogenetic Reconstruction[M]. Princeton University Press: Princeton, N.J.Meléndez LV, Hunt RD, Daniel MD, García FG, Fraser CE. 1969. Herpesvirus saimiri. II. Experimentally induced malignant lymphoma in primates [J]. Lab Anim Care, 19(3): 378-386.Morera Y, Bequet-Romero M, Ayala M, Velazco JC, Pérez PP, Alba JS, Ancizar J, Rodríguez M, Cosme K, Gavilondo JV. 2010. Immunogenicity and some safety features of a VEGF-based cancer therapeutic vaccine in rats, rabbits and non-human primates [J]. Vaccine, 28(19): 3453-3461. Murphey-Corb M, Martin LN, Rangan SR, Baskin GB, Gormus BJ, Wolf RH, Andes WA, West M, Montelaro RC. 1986. Isolation of an HTLV-III-related retrovirus from macaques with simian AIDS and its possible origin in asymptomatic mangabeys [J]. Nature, 321(6068): 435-437.Niu Y, Yu Y, Bernat A, Yang S, He X, Guo X, Chen D, Chen Y, Ji S, Si W, Lv Y, Tan T, Wei Q, Wang H, Shi L, Guan J, Zhu X, Afanassieff M, Savatier P, Zhang K, Zhou Q, Ji W. 2010. Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vector [J]. Proc Natl Acad Sci U S A, 107(41): 17663-17667. Oda T, Murakami K, Nishizono A, Kodama M, Nasu M, Fujioka T. 2002. Long-term Helicobacter pylori infection in Japanese monkeys induces atrophic gastritis and accumulation of mutations in the p53 tumor suppressor gene [J]. Helicobacter, 7(3): 143-151.Ogura K, Maeda S, Nakao M, Watanabe T, Tada M, Kyutoku T, Yoshida H, Shiratori Y, Omata M. 2000. Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil [J]. J Exp Med, 192(11): 1601-1610.Ohgaki H, Hasegawa H, Kusama K, Morino K, Matsukura N, Sato S, Maruyama K, Sugimura T. 1986. Induction of gastric carcinomas in nonhuman primates by N-ethyl-N'-nitro-N-nitrosoguanidine [J]. J Natl Cancer Inst, 77(1): 179-186.Palotay JL, Adachi K, Dobson RL, Pinto JS. 1976. Carcinogen-induced cutaneous neoplasms in nonhuman primates [J]. J Natl Cancer Inst, 57(6): 1269-1274.Park US, Su JJ, Ban KC, Qin L, Lee EH, Lee YI. 2000. Mutations in the p53 tumor suppressor gene in tree shrew hepatocellular carcinoma associated with hepatitis B virus infection and intake of aflatoxin B1 [J]. Gene, 251(1): 73-80.Parker SE, Vahlsing HL, Serfilippi LM, Franklin CL, Doh SG, Gromkowski SH, Lew D, Manthorpe M, Norman J. 1995. Cancer gene therapy using plasmid DNA: safety evaluation in rodents and non-human primates [J]. Hum Gene Ther, 6(5): 575-590.Parkin DM. 2006. The global health burden of infection-associated cancers in the year 2002 [J]. Int J Cancer, 118(12): 3030-3044.Parsonnet J, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N, Sibley RK. 1991. Helicobacter pylori infection and the risk of gastric carcinoma [J]. N Engl J Med, 325(16):        1127-1131.Pavlicek A, Noskov VN, Kouprina N, Barrett JC, Jurka J, Larionov V. 2004. Evolution of the tumor suppressor BRCA1 locus in primates: implications for cancer predisposition [J]. Hum Mol Genet, 13(22): 2737-2751. Pellegrini G, Bienvenu JG, Meehan JT, Mischler SA, Perry RW, Scott DW, Anderson WI. 2009. Cutaneous melanoma with metastasis in a cynomolgus monkey (Macaca fascicularis) [J]. J Med Primatol, 38(6): 444-447. Pfeiffer CA, Allen E. 1948. Attempts to produce cancer in rhesus monkeys with carcinogenic hydrocarbons and estrogens [J]. Cancer Res, 8(3): 97-127.Puente XS, Velasco G, Gutiérrez-Fernández A, Bertranpetit J, King MC, López-Otín C. 2006. Comparative analysis of cancer genes in the human and chimpanzee genomes [J]. BMC Genomics, 7: 15.Putkonen P, Kaaya EE, Böttiger D, Li SL, Nilsson C, Biberfeld P, Biberfeld G. 1992. Clinical features and predictive markers of disease progression in cynomolgus monkeys experimentally infected with simian immunodeficiency virus [J]. AIDS, 6(3):   257-263.Rao MS, Reddy JK. 1980. Carcinogenicity of 2,2'-dihydroxy-di-n-propylnitrosamine in the tree shrew (Tupaia glis): light and electron microscopic features of pulmonary adenomas [J]. J Natl Cancer Inst, 65(4): 835-840.Reddy JK, Svoboda DJ, Rao MS. 1976. Induction of liver tumors by aflatoxin B1 in the tree shrew (Tupaia glis), a nonhuman primate [J]. Cancer Res, 36(1): 151-160.Rhesus Macaque Genome Sequencing and Analysis Consortium, Gibbs RA, Rogers J, Katze MG, Bumgarner R, Weinstock GM, Mardis ER, Remington KA, Strausberg RL, Venter JC, Wilson RK, Batzer MA, Bustamante CD, Eichler EE, Hahn MW, Hardison RC, Makova KD, Miller W, Milosavljevic A, Palermo RE, Siepel A, Sikela JM, Attaway T, Bell S, Bernard KE, Buhay CJ, Chandrabose MN, Dao M, Davis C, Delehaunty KD, Ding Y, Dinh HH, Dugan-Rocha S, Fulton LA, Gabisi RA, Garner TT, Godfrey J, Hawes AC, Hernandez J, Hines S, Holder M, Hume J, Jhangiani SN, Joshi V, Khan ZM, Kirkness EF, Cree A, Fowler RG, Lee S, Lewis LR, Li Z, Liu YS, Moore SM, Muzny D, Nazareth LV, Ngo DN, Okwuonu GO, Pai G, Parker D, Paul HA, Pfannkoch C, Pohl CS, Rogers YH, Ruiz SJ, Sabo A, Santibanez J, Schneider BW, Smith SM, Sodergren E, Svatek AF, Utterback TR, Vattathil S, Warren W, White CS, Chinwalla AT, Feng Y, Halpern AL, Hillier LW, Huang X, Minx P, Nelson JO, Pepin KH, Qin X, Sutton GG, Venter E, Walenz BP, Wallis JW, Worley KC, Yang SP, Jones SM, Marra MA, Rocchi M, Schein JE, Baertsch R, Clarke L, Csürös M, Glasscock J, Harris RA, Havlak P, Jackson AR, Jiang H, Liu Y, Messina DN, Shen Y, Song HX, Wylie T, Zhang L, Birney E, Han K, Konkel MK, Lee J, Smit AF, Ullmer B, Wang H, Xing J, Burhans R, Cheng Z, Karro JE, Ma J, Raney B, She X, Cox MJ, Demuth JP, Dumas LJ, Han SG, Hopkins J, Karimpour-Fard A, Kim YH, Pollack JR, Vinar T, Addo-Quaye C, Degenhardt J, Denby A, Hubisz MJ, Indap A, Kosiol C, Lahn BT, Lawson HA, Marklein A, Nielsen R, Vallender EJ, Clark AG, Ferguson B, Hernandez RD, Hirani K, Kehrer-Sawatzki H, Kolb J, Patil S, Pu LL, Ren Y, Smith DG, Wheeler DA, Schenck I, Ball EV, Chen R, Cooper DN, Giardine B, Hsu F, Kent WJ, Lesk A, Nelson DL, O'brien WE, Prüfer K, Stenson PD, Wallace JC, Ke H, Liu XM, Wang P, Xiang AP, Yang F, Barber GP, Haussler D, Karolchik D, Kern AD, Kuhn RM, Smith KE, Zwieg AS. 2007. Evolutionary and biomedical insights from the rhesus macaque genome [J]. Science, 316(5822): 222-234.Roberts TG Jr, Goulart BH, Squitieri L, Stallings SC, Halpern EF, Chabner BA, Gazelle GS, Finkelstein SN, Clark JW. 2004. Trends in the risks and benefits to patients with cancer participating in phase 1 clinical trials [J]. JAMA, 292(17): 2130-2140.Rodriguez GC, Walmer DK, Cline M, Krigman H, Lessey BA, Whitaker RS, Dodge R, Hughes CL. 1998. Effect of progestin on the ovarian epithelium of macaques: cancer prevention through apoptosis [J]? J Soc Gynecol Investig, 5(5): 271-276.Schoeffner DJ, Thorgeirsson UP. 2000. Susceptibility of nonhuman primates to carcinogens of human relevance [J]. In Vivo, 14(1): 149-156.Shope T, Dechairo D, Miller G. 1973a. Malignant lymphoma in cotton-top marmosets after inoculation with Epstein-Barr virus [J]. Proc Natl Acad Sci U S A, 70(9): 2487-2491.Shope T, Miller G. 1973b. Epstein-Barr virus. Heterophile responses in squirrel monkeys inoculated with virus-transformed autologous leukocytes [J]. J Exp Med, 137(1): 140-147.Shuto R, Fujioka T, Kubota T, Nasu M. 1993. Experimental gastritis induced by Helicobacter pylori in Japanese monkeys [J]. Infect Immun, 61(3): 933-939.Sieber SM, Correa P, Dalgard DW, Adamson RH. 1978. Carcinogenic and other adverse effects of procarbazine in nonhuman primates [J]. Cancer Res, 38(7): 2125-2134.Sieber SM, Correa P, Dalgard DW, McIntire KR, Adamson RH. 1980. Carcinogenicity and hepatotoxicity of cycasin and its aglycone methylazoxymethanol acetate in nonhuman primates [J]. J Natl Cancer Inst, 65(1): 177-189.Sharashidze LK, Beniashvili DSh, Sherenesheva NI, Turkia NG. 1989. Induction of gastric cancer in monkeys by N-methyl-N-nitro-N-nitrosoguanidine (MNNG) [J]. Neoplasma, 36(2): 129-133.Spittle MF. 1998. Spectrum of AIDS-associated malignant disorders [J]. Lancet, 352(9131): 907.Su JJ, Ban KC, Li Y, Qin LL, Wang HY, Yang C, Ou C, Duan XX, Lee YL, Yang RQ. 2004. Alteration of p53 and p21 during hepatocarcinogenesis in tree shrews [J]. World J Gastroenterol, 10(24): 3559-3563.Starost MF. 2009. Adenomyofibroma of the fimbria in a cynomolgus monkey (Macaca fascicularis) [J]. J Vet Diagn Invest, 21(6):    892-894.Takayama S, Renwick AG, Johansson SL, Thorgeirsson UP, Tsutsumi M, Dalgard DW, Sieber SM. 2000. Long-term toxicity and carcinogenicity study of cyclamate in nonhuman primates [J]. Toxicol Sci, 53(1): 33-39.Takayama S, Sieber SM, Adamson RH, Thorgeirsson UP, Dalgard DW, Arnold LL, Cano M, Eklund S, Cohen SM. 1998. Long-term feeding of sodium saccharin to nonhuman primates: implications for urinary tract cancer [J]. J Natl Cancer Inst, 90(1): 19-25.Takayama S, Sieber SM, Dalgard DW, Thorgeirsson UP, Adamson RH. 1999. Effects of long-term oral administration of DDT on nonhuman primates [J]. J Cancer Res Clin Oncol, 125(3-4): 219-225.Takayama S, Thorgeirsson UP, Adamson RH. 2008. Chemical carcinogenesis studies in nonhuman primates [J]. Proc Jpn Acad Ser B Phys Biol Sci, 84(6): 176-188. Tavassoli FA, Casey HW, Norris HJ. 1988. The morphologic effects of synthetic reproductive steroids on the mammary gland of rhesus monkeys. Mestranol, ethynerone, mestranol-ethynerone, chloroethynyl norgestrel-mestranol, and anagestone acetate-mestranol combinations [J]. Am J Pathol, 131(2): 213-234.Thorgeirsson UP, Dalgard DW, Reeves J, Adamson RH. 1994. Tumor incidence in a chemical carcinogenesis study of nonhuman primates [J]. Regul Toxicol Pharmacol, 19(2): 130-151.Yamate J, Tomita A, Kuwamura M, Mitsunaga F, Nakamura S. 2007. Spontaneous peritoneal malignant mesothelioma in a geriatric japanese macaque (Macaca fuscata) [J]. Exp Anim, 56(2): 155-159.Yan RQ, Su JJ, Huang DR, Gan YC, Yang C, Huang GH. 1996. Human hepatitis B virus and hepatocellular carcinoma. II. Experimental induction of hepatocellular carcinoma in tree shrews exposed to hepatitis B virus and aflatoxin B1 [J]. J Cancer Res Clin Oncol, 122(5): 289-295.Uno H, Alsum P, Zimbric ML, Houser WD, Thomson JA, Kemnitz JW. 1998. Colon cancer in aged captive rhesus monkeys (Macaca mulatta) [J]. Am J Primatol, 44(1): 19-27. Valerio MG. 1989. Comparative aspects of contraceptive steroids: effects observed in the monkey [J]. Toxicol Pathol, 17(2): 401-410.Wakisaka S, Kemper TL, Nakagaki H, O'Neill RR. 1982. Brain tumors induced by radiation in rhesus monkeys [J]. Fukuoka Igaku Zasshi, 73(10): 585-594.Werner J, Henle G, Pinto CA, Haff RF, Henle W. 1972. Establishment of continuous lymphoblast cultures from leukocytes of gibbons (Hylobates lar) [J]. Int J Cancer, 10(3): 557-567.Wood CE, Register TC, Lees CJ, Chen H, Kimrey S, Cline JM. 2007. Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys [J]. Breast Cancer Res Treat, 101(2): 125-134.Wood CE, Usborne AL, Starost MF, Tarara RP, Hill LR, Wilkinson LM, Geisinger KR, Feiste EA, Cline JM. 2006. Hyperplastic and neoplastic lesions of the mammary gland in macaques [J]. Vet Pathol, 43(4): 471-483. Wood DH. 1991. Long-term mortality and cancer risk in irradiated rhesus monkeys [J]. Radiat Res, 126(2): 132-140.Wright JW, Stouffer RL, Rodland KD. 2005. High-dose estrogen and clinical selective estrogen receptor modulators induce growth arrest, p21, and p53 in primate ovarian surface epithelial cells [J]. J Clin Endocrinol Metab, 90(6): 3688-3695.
  • 加载中
  • 文章访问数:  4366
  • HTML全文浏览量:  357
  • PDF下载量:  3758
  • 被引次数: 0
  • 收稿日期:  2010-12-14
  • 修回日期:  2011-01-07
  • 刊出日期:  2011-02-22