Application Studies of Animal Models in Evaluating Safety and Efficacy of HIV-1 Microbicides
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摘要: HIV/AIDS的流行趋势没有减弱的迹象，人们迫切需要新的预防HIV传播的手段。杀微生物剂旨在通过局部用药于阴道或直肠从而阻止HIV的传播。鉴于目前有大量的杀微生物剂候选物，亟待能够有效评价其有效性及安全性的动物模型。通过比较非灵长类小型动物模型与非人灵长类动物模型在评价HIV杀微生物剂的有效性及安全性上的重要作用，本文总结了评价杀微生物剂有效性及安全性的动物模型的优缺点，同时指出了杀微生物剂研究与发展的方向和建议，希望能够对杀微生物剂的研发有所帮助。Abstract: As the HIV/AIDS pandemic continues unabated, novel prophylactic strategy for the spread of HIV are urgently needed. Topical microbicides are designed to prevent transmission of HIV when applied vaginally or rectally. Although there are many microbicide candidates in the pipeline, animal models for evaluating their safety and efficacy are urgently needed. On the basis of comparing the non-primate small animal models and the non-human primate animal models in evaluating safety and efficacy of HIV microbicides, this review summarizes the major advantages and disadvantages of the relevant animal models. The suggested direction of research that would benefit the development of microbicides is also reviewed.
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Key words:
- HIV-1 /
- Sexual transmission /
- Microbicide /
- Safety and efficacy /
- Animal model
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