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赵艳, 王常乐, 高志云, 乔红秀, 王卫杰, 刘欣燕, 揣侠. 2023: 雪貂: SARS-CoV-2的强大模型. 动物学研究, 44(2): 323-330. DOI: 10.24272/j.issn.2095-8137.2022.351
引用本文: 赵艳, 王常乐, 高志云, 乔红秀, 王卫杰, 刘欣燕, 揣侠. 2023: 雪貂: SARS-CoV-2的强大模型. 动物学研究, 44(2): 323-330. DOI: 10.24272/j.issn.2095-8137.2022.351
Yan Zhao, Chang-Le Wang, Zhi-Yun Gao, Hong-Xiu Qiao, Wei-Jie Wang, Xin-Yan Liu, Xia Chuai. 2023: Ferrets: A powerful model of SARS-CoV-2. Zoological Research, 44(2): 323-330. DOI: 10.24272/j.issn.2095-8137.2022.351
Citation: Yan Zhao, Chang-Le Wang, Zhi-Yun Gao, Hong-Xiu Qiao, Wei-Jie Wang, Xin-Yan Liu, Xia Chuai. 2023: Ferrets: A powerful model of SARS-CoV-2. Zoological Research, 44(2): 323-330. DOI: 10.24272/j.issn.2095-8137.2022.351

雪貂: SARS-CoV-2的强大模型

Ferrets: A powerful model of SARS-CoV-2

  • 摘要: 新型冠状病毒(SARS-CoV-2)在全球范围内迅速传播,给世界各地带来了巨大的社会、经济和卫生负担。尽管各国在抗击新冠病毒方面做出了巨大努力,但仍有大量的SARS-CoV-2变异株被发现,且其致病性机制在很大程度上仍不清楚,而有效的治疗药物也正在研发中。理想的动物模型对于研究COVID-19的发病机制和针对SARS-CoV-2及其变异株感染的疫苗和抗病毒药物临床前评估至关重要。目前,已经建立的COVID-19的动物模型有小鼠、仓鼠、雪貂和非人灵长类动物(NHPs)等。其中,雪貂天然对SARS-CoV-2易感,被认为是最适合进行COVID-19研究的动物模型之一。该文对SARS-CoV-2雪貂模型在SARS-CoV-2发病机制、药物和疫苗方面的研究进展及应用进行了综述,并对该动物模型在预防新冠病毒传播中的作用进行了展望。

     

    Abstract: The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in recent years not only caused a global pandemic but resulted in enormous social, economic, and health burdens worldwide. Despite considerable efforts to combat coronavirus disease 2019 (COVID-19), various SARS-CoV-2 variants have emerged, and their underlying mechanisms of pathogenicity remain largely unknown. Furthermore, effective therapeutic drugs are still under development. Thus, an ideal animal model is crucial for studying the pathogenesis of COVID-19 and for the preclinical evaluation of vaccines and antivirals against SARS-CoV-2 and variant infections. Currently, several animal models, including mice, hamsters, ferrets, and non-human primates (NHPs), have been established to study COVID-19. Among them, ferrets are naturally susceptible to SARS-CoV-2 infection and are considered suitable for COVID-19 study. Here, we summarize recent developments and application of SARS-CoV-2 ferret models in studies on pathogenesis, therapeutic agents, and vaccines, and provide a perspective on the role of these models in preventing COVID-19 spread.

     

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