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Whole-genome resequencing infers genomic basis of giant phenotype in Siamese fighting fish (Betta splendens)

Le Wang Fei Sun May Lee Gen-Hua Yue

Le Wang, Fei Sun, May Lee, Gen-Hua Yue. Whole-genome resequencing infers genomic basis of giant phenotype in Siamese fighting fish (Betta splendens). Zoological Research, 2022, 43(1): 78-80. doi: 10.24272/j.issn.2095-8137.2021.266
Citation: Le Wang, Fei Sun, May Lee, Gen-Hua Yue. Whole-genome resequencing infers genomic basis of giant phenotype in Siamese fighting fish (Betta splendens). Zoological Research, 2022, 43(1): 78-80. doi: 10.24272/j.issn.2095-8137.2021.266

基因组重测序揭示暹罗斗鱼巨斗的遗传基础

doi: 10.24272/j.issn.2095-8137.2021.266

Whole-genome resequencing infers genomic basis of giant phenotype in Siamese fighting fish (Betta splendens)

Funds: This research was supported by the Internal Funds of the Temasek Life Sciences Laboratory (5020)
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  • 摘要: 了解驯化的遗传基础对于进化生物学和经济形状的遗传改良具有重要意义。暹罗斗鱼的巨大体型形状(巨斗)为研究体型过度生长的遗传机制提供了一个独特的样本。我们重测序和分析了54条斗鱼的基因组。基于3582429个SNPS,全基因组水平的FST和选择性分析扫描到了三个与巨斗相关的基因组区域。这三个区域分别位于1,9 和11号染色体上,总长度为3.5 Mb。这三个染色体区域在巨斗和普通斗鱼之间呈现出高度的遗传分化,并且在巨斗中具有明显的选择性信号。相比之下,在野生斗鱼中我们并未检测到选择性信号。对巨斗和普通斗鱼的大脑和肌肉样本进行的转录组分析,发现了14个可能与巨斗相关的候选基因。这些研究为了解体型变异的遗传机制提供了新的见解,并为进化生物学研究以及生长性状的快速遗传改良提供了重要资源。
  • Figure  1.  Population structure of fighting fish (Betta splendens)

    A: Giant and normal bettas. B: LD decay among wild-type, giant, and normal bettas. C, D: Population structure within betta fish and between giant and normal bettas, respectively, as revealed by PCA. E: Ancestral genetic clusters among wild-type, giant, and normal bettas, as revealed by admixture analysis.

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  • ZR-2021-266 Supplementary Materials.pdf
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出版历程
  • 收稿日期:  2021-09-18
  • 录用日期:  2021-12-03
  • 网络出版日期:  2021-12-05
  • 刊出日期:  2022-01-18

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