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宋天章, 郑宏毅, 韩建保, 冯小丽, 刘丰亮, 杨翔, 靳林, 罗荣华, 田仁荣, 刘超, 李明华, 蔡后荣, 郑永唐. 2021: SARS-CoV-2感染北平顶猴(Macaca leonina)呈现病毒快速清除及持续的免疫反应. 动物学研究, 42(3): 350-353. DOI: 10.24272/j.issn.2095-8137.2020.334
引用本文: 宋天章, 郑宏毅, 韩建保, 冯小丽, 刘丰亮, 杨翔, 靳林, 罗荣华, 田仁荣, 刘超, 李明华, 蔡后荣, 郑永唐. 2021: SARS-CoV-2感染北平顶猴(Macaca leonina)呈现病毒快速清除及持续的免疫反应. 动物学研究, 42(3): 350-353. DOI: 10.24272/j.issn.2095-8137.2020.334
Tian-Zhang Song, Hong-Yi Zheng, Jian-Bao Han, Xiao-Li Feng, Feng-Liang Liu, Xiang Yang, Lin Jin, Rong-Hua Luo, Ren-Rong Tian, Chao Liu, Ming-Hua Li, Hou-Rong Cai, Yong-Tang Zheng. 2021: Northern pig-tailed macaques (Macaca leonina) infected with SARS-CoV-2 show rapid viral clearance and persistent immune response. Zoological Research, 42(3): 350-353. DOI: 10.24272/j.issn.2095-8137.2020.334
Citation: Tian-Zhang Song, Hong-Yi Zheng, Jian-Bao Han, Xiao-Li Feng, Feng-Liang Liu, Xiang Yang, Lin Jin, Rong-Hua Luo, Ren-Rong Tian, Chao Liu, Ming-Hua Li, Hou-Rong Cai, Yong-Tang Zheng. 2021: Northern pig-tailed macaques (Macaca leonina) infected with SARS-CoV-2 show rapid viral clearance and persistent immune response. Zoological Research, 42(3): 350-353. DOI: 10.24272/j.issn.2095-8137.2020.334

SARS-CoV-2感染北平顶猴(Macaca leonina)呈现病毒快速清除及持续的免疫反应

Northern pig-tailed macaques (Macaca leonina) infected with SARS-CoV-2 show rapid viral clearance and persistent immune response

  • 摘要: SARS-CoV-2感染引起的新型冠状病毒肺炎疫情已成为21世纪全球最重要的公共卫生突发事件。目前,SARS-CoV-2感染非人灵长类动物模型被认为是进行新型冠状病毒肺炎病理损伤特征及致病机制研究的金标准。该研究中,我们成功构建SARS-CoV-2感染北平顶猴(Macaca leonina)实验动物模型,发现北平顶猴可有效支持病毒复制。与恒河猴实验动物模型相比,SARS-CoV-2感染北平顶猴肺组织、鼻拭子、咽拭子及肛拭子中病毒快速清除,这可能与北平顶猴感染后肺组织中干扰素的高表达有关。但是,与恒河猴相比,感染后第二周北平顶猴呈现持续甚至更为严重的炎症反应及临床症状。上述结果表明,病毒清除可能与新型冠状病毒肺炎的疾病进展无关,SARS-CoV-2感染北平顶猴可被视为重症模型用于新型冠状病毒肺炎相关研究。

     

    Abstract: Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2), has become an unprecedented global health emergency. At present, SARS-CoV-2-infected nonhuman primates are considered the gold standard animal model for COVID-19 research. Here, we showed that northern pig-tailed macaques (Macaca leonina, NPMs) supported SARS-CoV-2 replication. Furthermore, compared with rhesus macaques, NPMs showed rapid viral clearance in lung tissues, nose swabs, throat swabs, and rectal swabs, which may be due to higher expression of interferon (IFN)-α in lung tissue. However, the rapid viral clearance was not associated with good outcome. In the second week post infection, NPMs developed persistent or even more severe inflammation and body injury compared with rhesus macaques. These results suggest that viral clearance may have no relationship with COVID-19 progression and SARS-CoV-2-infected NPMs could be considered as a critically ill animal model in COVID-19 research.

     

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