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李臻慧, 何夏萍, 李浩, 赫荣乔, 胡新天. 2020: 猕猴脑脊液中淀粉样蛋白和甲醛浓度的年龄相关性变化. 动物学研究, 41(4): 444-448. DOI: 10.24272/j.issn.2095-8137.2020.088
引用本文: 李臻慧, 何夏萍, 李浩, 赫荣乔, 胡新天. 2020: 猕猴脑脊液中淀粉样蛋白和甲醛浓度的年龄相关性变化. 动物学研究, 41(4): 444-448. DOI: 10.24272/j.issn.2095-8137.2020.088
Zhen-Hui Li, Xia-Ping He, Hao Li, Rong-Qiao He, Xin-Tian Hu. 2020: Age-associated changes in amyloid-β and formaldehyde concentrations in cerebrospinal fluid of rhesus monkeys. Zoological Research, 41(4): 444-448. DOI: 10.24272/j.issn.2095-8137.2020.088
Citation: Zhen-Hui Li, Xia-Ping He, Hao Li, Rong-Qiao He, Xin-Tian Hu. 2020: Age-associated changes in amyloid-β and formaldehyde concentrations in cerebrospinal fluid of rhesus monkeys. Zoological Research, 41(4): 444-448. DOI: 10.24272/j.issn.2095-8137.2020.088

猕猴脑脊液中淀粉样蛋白和甲醛浓度的年龄相关性变化

Age-associated changes in amyloid-β and formaldehyde concentrations in cerebrospinal fluid of rhesus monkeys

  • 摘要: 猕猴在进化上与人类关系密切,是研究神经退行性疾病的重要实验动物,猕猴也会表现出与人类相似的衰老和神经退化特征,比如大脑中老年斑的形成。然而,随着猕猴的衰老,其脑脊液中甲醛含量的变化尚未见报道,脑脊液中甲醛的变化是否与淀粉样蛋白(Aβ)的浓度变化相关也未曾被关注过。在本研究中,我们测量了56只猕猴(年龄从2岁到26岁)的脑脊液中Aβ40、Aβ42和甲醛的浓度。结果显示,随着猕猴年龄的增长,其脑脊液中的Aβ40和Aβ42浓度有显著下降的趋势,而甲醛浓度则显著升高。有趣的是,我们发现甲醛浓度的升高与Aβ40和Aβ42浓度在老年组猕猴中为显著负相关,而在年轻和中年猕猴组中则没有显著相关性。这样的结果与人类衰老过程中出现的变化类似,在正常老年人和阿尔茨海默病(AD)患者中,脑脊液Aβ浓度下降,而甲醛浓度升高。本研究结果不但进一步证明猕猴是研究年龄相关神经系统疾病(比如AD)的可靠实验动物,而且提示甲醛可能参与了衰老和AD的发生发展,为甲醛作为AD的早期诊断指标提供理论依据。

     

    Abstract: Rhesus monkeys (Macaca mulatta) are valuable experimental animals for studies on neurodegenerative diseases due to their evolutionarily close relationship to humans (Zhang et al., 2014). Rhesus monkeys also display similar hallmarks of aging and neurodegeneration as humans, including formation of senile plaques in the brain (Beckman et al., 2019; Paspalas et al., 2018). However, changes in formaldehyde (FA) levels in the cerebrospinal fluid (CSF) of rhesus monkeys with aging have not been reported. Additionally, whether changes in CSF FA are correlated with changes in amyloid-β (Aβ) concentrations have not yet been explored. Here, the CSF levels of Aβ40, Aβ42, and FA were measured in 56 rhesus monkeys of different ages, ranging from 4 to 26 years old. Results revealed significant declines in Aβ40 and Aβ42, and an increase in FA with age. Interestingly, the increase in FA levels was negatively correlated with Aβ40 and Aβ42 concentrations in aged rhesus monkeys but not in young and middle-aged monkeys. These results appear to parallel changes seen within human aging, i.e., decreased levels of CSF Aβ and increased levels of FA in normal aged adults and Alzheimer’s disease (AD) patients. These findings further indicate that rhesus monkeys are a reliable model for studying age-related neurological disorders such as AD and suggest that FA is an important factor in AD development and may be used as a diagnostic indicator of such disease.

     

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