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张美玲, 李明莉, Adeola Oluwakemi Ayoola, Robert W. Murphy, 吴东东, 邵永. 2019: 利用全基因组保守序列确认现存灵长类的最近姐妹支系. 动物学研究, 40(6): 532-540. DOI: 10.24272/j.issn.2095-8137.2019.057
引用本文: 张美玲, 李明莉, Adeola Oluwakemi Ayoola, Robert W. Murphy, 吴东东, 邵永. 2019: 利用全基因组保守序列确认现存灵长类的最近姐妹支系. 动物学研究, 40(6): 532-540. DOI: 10.24272/j.issn.2095-8137.2019.057
Mei-Ling Zhang, Ming-Li Li, Adeola Oluwakemi Ayoola, Robert W. Murphy, Dong-Dong Wu, Yong Shao. 2019: Conserved sequences identify the closest living relatives of primates. Zoological Research, 40(6): 532-540. DOI: 10.24272/j.issn.2095-8137.2019.057
Citation: Mei-Ling Zhang, Ming-Li Li, Adeola Oluwakemi Ayoola, Robert W. Murphy, Dong-Dong Wu, Yong Shao. 2019: Conserved sequences identify the closest living relatives of primates. Zoological Research, 40(6): 532-540. DOI: 10.24272/j.issn.2095-8137.2019.057

利用全基因组保守序列确认现存灵长类的最近姐妹支系

Conserved sequences identify the closest living relatives of primates

  • 摘要: 阐明现存灵长类近亲的系统发育关系对于深入理解灵长类(特别是人类)基因组和遗传表型进化等相关生物学问题至关重要。然而,目前灵长类近亲的系统发育关系仍然存有较大争议,形态学和分子生物学证据普遍支持三种主要的假说:(1)树鼩是灵长类的姐妹进化支系;(2)树鼩和皮翼类共同作为灵长类的姐妹进化支系;(3)皮翼类是灵长类的姐妹进化支系)。在本研究中,我们使用两种序列划分策略(45 Mb全基因组保守非编码元件和393 kb串联蛋白编码基因序列;它们分别代表不同进化速率的基因组区域)来探讨上述三种假说的正确性。相比于其它系统发育分子生物学研究,本研究评估了灵长类及其近亲的基因组进化历史,该结果稳固地支持第三种假说—皮翼类是现存灵长类的最近姐妹进化支系。同时,我们的系统发育研究表明猴亚科基因组(特别是狒狒族)具有较低的核苷酸分歧水平,而长臂猿基因组拥有较高的核苷酸分歧速率。此外,我们使用MCMCtree方法进一步更新了灵长类小目以及灵长类早期进化支系的分歧时间。

     

    Abstract: Elucidating the closest living relatives of extant primates is essential for fully understanding important biological processes related to the genomic and phenotypic evolution of primates, especially of humans. However, the phylogenetic placement of these primate relatives remains controversial, with three primary hypotheses currently espoused based on morphological and molecular evidence. In the present study, we used two algorithms to analyze differently partitioned genomic datasets consisting of 45.4 Mb of conserved non-coding elements and 393 kb of concatenated coding sequences to test these hypotheses. We assessed different genomic histories and compared with other molecular studies found solid support for colugos being the closest living relatives of primates. Our phylogeny showed Cercopithecinae to have low levels of nucleotide divergence, especially for Papionini, and gibbons to have a high rate of divergence. The MCMCtree comprehensively updated divergence dates of early evolution of Primatomorpha and Primates.

     

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