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王颂基, 邱香果. 2018: 敲除I型干扰素受体的小鼠作为感染具有爆发潜力的高致病性病毒的动物模型. 动物学研究, 39(1): 3-14. DOI: 10.24272/j.issn.2095-8137.2017.052
引用本文: 王颂基, 邱香果. 2018: 敲除I型干扰素受体的小鼠作为感染具有爆发潜力的高致病性病毒的动物模型. 动物学研究, 39(1): 3-14. DOI: 10.24272/j.issn.2095-8137.2017.052
Gary Wong, Xiang-Guo Qiu. 2018: Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential. Zoological Research, 39(1): 3-14. DOI: 10.24272/j.issn.2095-8137.2017.052
Citation: Gary Wong, Xiang-Guo Qiu. 2018: Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential. Zoological Research, 39(1): 3-14. DOI: 10.24272/j.issn.2095-8137.2017.052

敲除I型干扰素受体的小鼠作为感染具有爆发潜力的高致病性病毒的动物模型

Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential

  • 摘要: 由于无法产生完全的免疫反应,敲除I型干扰素受体(Ifnar-/-)的小鼠更容易受到病毒感染,因此被广泛用于发病机制研究。这种小鼠模型已被用于研究包括黄病毒科、丝状病毒科、阿拉维病毒科、布尼亚病毒科、麻疹病毒科和披膜病毒科等高致病性病毒引起的许多疾病。在这篇综述中,我们总结了这些动物研究的结果,并讨论了该模型与已知其他研究动物发病机制的方法相比较的优点和缺点。

     

    Abstract: Due to their inability to generate a complete immune response, mice knockout for type I interferon (IFN) receptors (Ifnar–/–) are more susceptible to viral infections, and are thus commonly used for pathogenesis studies. This mouse model has been used to study many diseases caused by highly pathogenic viruses from many families, including the Flaviviridae, Filoviridae, Arenaviridae, Bunyaviridae, Henipaviridae, and Togaviridae. In this review, we summarize the findings from these animal studies, and discuss the pros and cons of using this model versus other known methods for studying pathogenesis in animals.

     

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