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杨建荣. 2017: mRNA结构是否包含能调控蛋白质的伴翻译折叠的遗传信息?. 动物学研究, 38(1): 36-43. DOI: 10.13918/j.issn.2095-8137.2017.004
引用本文: 杨建荣. 2017: mRNA结构是否包含能调控蛋白质的伴翻译折叠的遗传信息?. 动物学研究, 38(1): 36-43. DOI: 10.13918/j.issn.2095-8137.2017.004
Jian-Rong Yang. 2017: Does mRNA structure contain genetic information for regulating co-translational protein folding?. Zoological Research, 38(1): 36-43. DOI: 10.13918/j.issn.2095-8137.2017.004
Citation: Jian-Rong Yang. 2017: Does mRNA structure contain genetic information for regulating co-translational protein folding?. Zoological Research, 38(1): 36-43. DOI: 10.13918/j.issn.2095-8137.2017.004

mRNA结构是否包含能调控蛋白质的伴翻译折叠的遗传信息?

Does mRNA structure contain genetic information for regulating co-translational protein folding?

  • 摘要: 人们目前对遗传信息很多方面的内涵尚知之甚少。特别是蛋白质折叠如何在遗传信息调控下进行,就是遗传学和蛋白质生物学中一个历史悠久的研究课题。但相关研究还缺乏一个既有普遍性,又得到基因组数据支持的机制模型。近来高通量测序技术的发展使研究上述问题的基因组水平实验成为可能。相关研究结果提示,mRNA结构可能通过影响翻译延伸速率来调节蛋白质折叠,而同义密码子的偏好性产生类似调节作用的能力却仍有待进一步确认。结合前人提出的理论,描述mRNA结构调节蛋白质折叠的这一机制模型,将拓展我们对遗传信息丰富内涵的认识,并为多种生物与医学问题的解决提供全新的思路。

     

    Abstract: Currently many facets of genetic information are ill-defined. In particular, how protein folding is genetically regulated has been a long-standing issue for genetics and protein biology. And a generic mechanistic model with supports of genomic data is still lacking. Recent technological advances have enabled much needed genome-wide experiments. While putting the effect of codon optimality on debate, these studies have supplied mounting evidence suggesting a role of mRNA structure in the regulation of protein folding by modulating translational elongation rate. In conjunctions with previous theories, this mechanistic model of protein folding guided by mRNA structure shall expand our understandings of genetic information and offer new insights into various biomedical puzzles.

     

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