The Lugu Lake, shared by Yunnan and Sichuan Province, is a fault lake in the Northwest of Yunnan Plateau in China. Its original fish fauna was composed of 4 species, including three Schizothorax species and Misgurnus anguillicaudatus. During our surveys to the Lugu Lake in 2001, 2002 and 2004, 518 specimens were collected and the current fish fauna was documented. Besides previous collections and abundant reports, 12 species have been recorded in the Lugu Lake, which belong to 10 genera, Four families and three orders. Change of fish fauna in the Lugu Lake was primarily due to over-fishing and debris flow caused by deforestation.