Volume 12 Issue 3
May  1991
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LIU Ai-hua HE Wei-shun LIN Shi-ying ZHAO Gui-fen SUN La-hua JI Xue-min LIU Chang-lin. Micronuclei of Rat Bone Marrow Cells and Lung Macrophages Induced by Five Kinds of Yunnan Tin Ore Powder and Four Kinds of Metallic Compound. Zoological Research, 1991, 12(3): 309-314.
Citation: LIU Ai-hua HE Wei-shun LIN Shi-ying ZHAO Gui-fen SUN La-hua JI Xue-min LIU Chang-lin. Micronuclei of Rat Bone Marrow Cells and Lung Macrophages Induced by Five Kinds of Yunnan Tin Ore Powder and Four Kinds of Metallic Compound. Zoological Research, 1991, 12(3): 309-314.

Micronuclei of Rat Bone Marrow Cells and Lung Macrophages Induced by Five Kinds of Yunnan Tin Ore Powder and Four Kinds of Metallic Compound

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 1991-08-22
  • This paper emphasizes on the correlation between the highoccurring occupational lung cancer and potential mutagenicity of five kinds of Yunnan tin ore powder and four kinds of metallic compound.After treatment of rats by administration through trachea with these ore powder and compounds,the cytological preparations are made at various intervals for observing the effects of these ore powder and metallic compound on the frequencies of micronucleus and karyorrhexis of rat bone marrow cells and lung macrophages.The results are as following:1.All the ore powder and two kinds of metallic compound SnO[2] and Fe[2]O[3] can induce micronuclei and karyorrhexis in bone marrow cells.On first and 10th day,the frequency of karyorrhexis is higher than that of micronuclei and differs significantly from that of the control and vice versa on 20th and 30th day.2.All of the ore powder and metallic compound can also induce micronuclei and karyorrhexis in lung macrophages,and on 10th and 20th day,the frequency of karyorrhexis is as the same as that in bone marrow cells.
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