NIU Hai-chen, SHANG Bin, SUN Ning-lei, LI Ling, GUAN Yi-liang, YU Hua-lin, Ma Yuan. 2008: Baclofen Inhibited the Morphine-induced Conditioned Placed Preference and Withdrawal Syndromes. Zoological Research, 29(6): 621-626. DOI: 10.3724/SP.J.1141.2008.06621
Citation: NIU Hai-chen, SHANG Bin, SUN Ning-lei, LI Ling, GUAN Yi-liang, YU Hua-lin, Ma Yuan. 2008: Baclofen Inhibited the Morphine-induced Conditioned Placed Preference and Withdrawal Syndromes. Zoological Research, 29(6): 621-626. DOI: 10.3724/SP.J.1141.2008.06621

Baclofen Inhibited the Morphine-induced Conditioned Placed Preference and Withdrawal Syndromes

  • The mice with a continuous 7-day intraperitoneal injection of morphine was induced the conditioned placed reference (CPP) model and the mice with a continuous 7-day subcutaneous injection of morphine(25, 50, 75, 100, 125, 150 mg/kg)was induced withdrawal model (jump behavior) by naloxone administration(6 mg/kg). The results suggested that the administration of the GABAB receptor agonist, baclofen, could effectively attenuate the expression of CPP and the nalxone-induced response in the mice. It could be concluded that activating GABAB receptor can alleviate physical and psychic dependence syndromes to a certian extent .
  • loading

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return