三链DNA的研究进展
Progress in Studies on Triple Helix DNA
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摘要: 由于三链DNA可能存在于生命体系内,并且提供了基因调控、人造限制性内切酶以及阻止DNA和蛋白质结合等的新方法。三链DNA作为DNA结构多样性的一个主要研究方向,而受到人们越来越多的注意。本文综述了三链DNA结构和生物学意义的研究进展。Abstract: DNA triplexes have been attracting considerable attention in recent years because more and more evidence supports the existence of triplex DNA in vivo and the possible application of triplex DNA as artificial endonuclease,gene regulation.The structural basis,classify and biological significance of triplex formation are discussed.In finally,the prospect of further developing triplex trsearch is given.