浙江产蝮蛇(Agkistrodon halys Pallas)蛇毒纤溶组份对凝血系统的作用
The Action of Fibrinolytic Principle Obtained From the Venom of Agkistrodon Halys (Pallas) on Blood Coagulation System
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摘要: 用二乙氨基乙基葡聚糖A-50两次柱层析及葡聚糖凝胶过滤,从浙江产蝮蛇毒中得到一个纤溶组份。体内外试验研究表明,这一纤溶组份对纤维蛋白和纤维蛋白原均有显著的溶解作用,它也作用于第Ⅷ凝血因子和第Ⅴ凝血固子。浙江产蝮蛇毒纤溶组份的这些性质与血浆素(纤维蛋白溶酶)相似,因而是一种血浆素样物质。Abstract: The fibrinolytic principle was obtained by twice DEAE-Sephadex A-50 column chromatography and Sephadex G-100 gel filtration from the venom of Agkistrodon halys Pallas.The experiment both in vitro and in vivo suggests that the fibrinolytic principle has actions on fibrin and fibrinogen and is able to hydrolyze factor Ⅷ and factor Ⅴ.The properties of the fibrinolytic principle of Agkistrodon halys Pallas venom are similar to those of plasmin,therefore,it is a plasmin-like substance.