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董丽, 吕龙宝, 赖仞. 2012: 树鼩神经肽Y 的分子克隆及其灵长类类似物的同源性比较. 动物学研究, 33(1): 75-78. DOI: 10.3724/SP.J.1141.2012.01075
引用本文: 董丽, 吕龙宝, 赖仞. 2012: 树鼩神经肽Y 的分子克隆及其灵长类类似物的同源性比较. 动物学研究, 33(1): 75-78. DOI: 10.3724/SP.J.1141.2012.01075
DONG Li, LÜ Long-Bao, LAI Ren. 2012: Molecular cloning of Tupaia belangeri chinensis neuropeptide Y and homology comparison with other analogues from primates. Zoological Research, 33(1): 75-78. DOI: 10.3724/SP.J.1141.2012.01075
Citation: DONG Li, LÜ Long-Bao, LAI Ren. 2012: Molecular cloning of Tupaia belangeri chinensis neuropeptide Y and homology comparison with other analogues from primates. Zoological Research, 33(1): 75-78. DOI: 10.3724/SP.J.1141.2012.01075

树鼩神经肽Y 的分子克隆及其灵长类类似物的同源性比较

Molecular cloning of Tupaia belangeri chinensis neuropeptide Y and homology comparison with other analogues from primates

  • 摘要: 树鼩由于与灵长类动物有较密切的亲缘关系和其个体小,以及繁殖周期短等特性而倍受关注, 尤其是作为医用实验动物的研究,近年来已受到越来越多的重视, 但树鼩的分类地位还一直有所争论。该研究从树鼩脑cDNA 文库中克隆得到编码树鼩神经肽Y(neuropeptide Y, NPY)前体序列, 序列比对发现该序列与灵长类NPY 序列同源性高达96.9%。将该序列与GenBank 数据库中其他物种的NPY 序列构建系统进化树, 发现树鼩与灵长类处于同一分支。该研究结果揭示了树鼩与灵长类较近的亲缘关系。

     

    Abstract: Much attention has been payed to tree shrews for their close phylogenetic relationship with primates, small size, and short reproductive cycle. Especially, they are considered as excellent experiential animals for medicine or/and disease research. A nucleotide sequence encoding neuropeptide Y(NPY) precursor has been cloned from the cDNA library of Tupaia belangeri chinensis. Sequence alignment revealed that the sequence homology with primate NPY was up to 96.9%. The phylogenetic analysis based on NPY precursor sequence revealed that the tree shrew has a close relationship with primates.

     

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