Abstract: Schizophrenia is a complex mental disease which affects about 1% of the world population. Previous studies reported that the brain volumes of the schizophrenia patients were much smaller than normal people and many schizophrenia susceptible genetic variants were associated with structural brain abnormalities in patients, which is consistent with the neurodevelopmental hypothesis of the etiology of schizophrenia. Recently, two SNPs (rs2004888 and rs452256) of GULP1 were found to be significantly associated with schizophrenia. In this study, to test whether these two SNP of GULP1 are also consistent with the neurodevelopmental hypothesis, we genotyped the two SNPs in 791 Chinese individuals and measured their brain volumes.We found that the two SNPs have no association with brain volume, suggesting that the etiology of schizophrenia is much more complicated.