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高振华, 赵晖, 余果宇, 张云, 申吉泓, 李文辉. 2009: 人精液凝固蛋白Ⅰ衍生合成肽的抗菌活性. 动物学研究, 30(2): 178-184. DOI: 10.3724/SP.J.1141.2009.02178
引用本文: 高振华, 赵晖, 余果宇, 张云, 申吉泓, 李文辉. 2009: 人精液凝固蛋白Ⅰ衍生合成肽的抗菌活性. 动物学研究, 30(2): 178-184. DOI: 10.3724/SP.J.1141.2009.02178
Chen Xin-xin, Yu guo-yu, ZHAN Yan, Zhang Yun, Shen Ji-hong, Lee We. 2009: Antibacterial Activity Investigation of Human Semenogelin I Derived Peptides. Zoological Research, 30(2): 178-184. DOI: 10.3724/SP.J.1141.2009.02178
Citation: Chen Xin-xin, Yu guo-yu, ZHAN Yan, Zhang Yun, Shen Ji-hong, Lee We. 2009: Antibacterial Activity Investigation of Human Semenogelin I Derived Peptides. Zoological Research, 30(2): 178-184. DOI: 10.3724/SP.J.1141.2009.02178

人精液凝固蛋白Ⅰ衍生合成肽的抗菌活性

Antibacterial Activity Investigation of Human Semenogelin I Derived Peptides

  • 摘要: SgI-29是作者最新发现的有抗菌活性的人精液凝固蛋白I衍生抗菌肽。以SgI-29为模板,合成4种不同肽链长度的SgI-29衍生小肽,利用理化性质分析软件及螺旋轮作图法对SgI-29及其衍生物进行了理化性质及结构的预测,结合琼脂糖弥散法抗菌试验得到的不同合成肽段对大肠杆菌标准菌株(Escherichia coli ATCC 25922)以及绿脓杆菌标准株(Pseudomonas aeruginosa ATCC 27853)的抗菌活性实验结果,探讨了SgI-29及其衍生物的结构-功能关系。结果表明:SgI-22在所有的SgI-29及其衍生物中有最好的抗菌活性,是进行进一步结构优化的良好模板。

     

    Abstract: SgI-29 is a newly characterized antibacterial peptide derived from human semenogelin I. Using SgI-29 as model, 4 peptides with different length were synthesized. Physico-chemical characteristics and structure prediction of SgI-29 and its derived peptides were analyzed by software packages and helix-wheel plot. The antibacterial activities of SgI-29 and its derived peptides against Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853 were determined. The structure-function relationship of SgI-29 and its derivatives was analyzed. Our results indicated that SgI-22 has the strongest antibacterial activities against the tested bacteria among the synthetic peptides and might be used as a good model for the structure optimization.

     

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